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Infect Immun, April 1998, p. 1740-1743, Vol. 66, No. 4
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Comparison of an Adherence Domain and a Structural Region of Streptococcus mutans Antigen I/II in Protective Immunity against Dental Caries in Rats after Intranasal Immunization

George Hajishengallis,* Michael W. Russell, and Suzanne M. Michalek

Departments of Microbiology and Oral Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294

Received 23 October 1997/Returned for modification 12 January 1998/Accepted 23 January 1998

Previous studies have identified an N-terminal saliva-binding region (SBR) on Streptococcus mutans surface antigen I/II (AgI/II) and suggested its importance in the initial adherence of S. mutans to saliva-coated tooth surfaces and subsequent development of dental caries. In this study, we compared the SBR with a C-terminal structural region of AgI/II (AgII) in their abilities to induce protective immunity against caries in rats. When SBR, AgII, or the whole AgI/II molecule was administered intranasally as a conjugate with the B subunit of cholera toxin (CT), in the presence of CT adjuvant, substantial levels of salivary immunoglobulin A anti-AgI/II antibodies were induced. Evaluation of caries activity showed that the SBR, though not as protective as the parent molecule, was superior to AgII and thus can be further considered as a component in a multivalent caries vaccine.

* Corresponding author. Mailing address: Departments of Microbiology and Oral Biology, University of Alabama at Birmingham, 845 19th Street South, BBRB 634/Box 5, Birmingham, AL 35294-2170. Phone: (205) 934-3033. Fax: (205) 934-1426. E-mail: medm116{at}uabdpo.dpo.uab.edu.




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