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Infect Immun, April 1998, p. 1748-1751, Vol. 66, No. 4
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Adherence to and Penetration of Human Intestinal Caco-2 Epithelial Cell Monolayers by Pseudomonas aeruginosa

Yoichi Hirakata,1,* Kohichi Izumikawa,1 Toshiyuki Yamaguchi,1 Shizunobu Igimi,2 Nobuhiko Furuya,3 Shigefumi Maesaki,4 Kazunori Tomono,4 Yasuaki Yamada,1 Shigeru Kohno,4 Keizo Yamaguchi,3 and Shimeru Kamihira1

Department of Laboratory Medicine1 and Second Department of Internal Medicine,4 Nagasaki University School of Medicine, Nagasaki 852, Department of Biomedical Food Research, National Institute of Infectious Diseases, Tokyo 162,2 and Department of Microbiology, Toho University School of Medicine, Tokyo 143,3 Japan

Received 10 November 1997/Returned for modification 9 December 1997/Accepted 31 December 1997

Clinical isolates of Pseudomonas aeruginosa from blood adhered to and penetrated intestinal Caco-2 cell monolayers to a greater degree than did isolates from sputum, with a concomitant drastic decrease in transepithelial electrical resistance. PAO-PR1, an avirulent exotoxin A mutant of PAO1, did not cause a decrease in the resistance. The Caco-2 monolayer system may be useful for the evaluation of certain P. aeruginosa virulence factor activities.

* Corresponding author. Mailing address: Department of Laboratory Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852, Japan. Phone: 81 (95) 849-7418. Fax: 81 (95) 849-7257. E-mail: hirakata{at}net.nagasaki-u.ac.jp.




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