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Infect Immun, April 1998, p. 1752-1754, Vol. 66, No. 4
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Aging and the Immune Response to the Haemophilus influenzae Type b Capsular Polysaccharide: Retention of the Dominant Idiotype and Antibody Function in the Elderly

Alexander H. Lucas* and Donald C. Reason

Children's Hospital Oakland Research Institute, Oakland, California

Received 31 October 1997/Accepted 16 December 1997

Anti-Haemophilus influenzae b polysaccharide (Hib PS) antibodies elicited in elderly subjects following conjugate vaccination expressed a light-chain variable-region (VL)-associated idiotype and had functional activities similar to those previously observed in children and younger adults. These findings indicate that advanced age is not accompanied by shifts in the major VL component of the Hib PS-specific repertoire or by diminution of the protective function of antibodies.

* Corresponding author. Mailing address: Children's Hospital Oakland Research Institute, 747 52nd St., Oakland, CA 94609. Phone: (510) 428-3175. Fax: (510) 428-3608. E-mail: alucas{at}lanminds.com.




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Copyright © 1998 by the American Society for Microbiology. All rights reserved.