This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Laurent, F.
Right arrow Articles by Eckmann, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Laurent, F.
Right arrow Articles by Eckmann, L.

 Previous Article  |  Next Article 

Infect Immun, April 1998, p. 1787-1790, Vol. 66, No. 4
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Human Intestinal Epithelial Cells Respond to Cryptosporidium parvum Infection with Increased Prostaglandin H Synthase 2 Expression and Prostaglandin E2 and F2alpha Production

Fabrice Laurent,1 Martin F. Kagnoff,1 Tor C. Savidge,2,dagger Muriel Naciri,3 and Lars Eckmann1,*

Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California 920931; Department of Cellular Physiology, The Babraham Institute, Babraham, Cambridge CB2 4AT, United Kingdom2; and Laboratoire de Protozoologie, Centre INRA de Tours, 37380 Nouzilly, France3

Received 7 October 1997/Returned for modification 6 November 1997/Accepted 14 January 1998

Cryptosporidium parvum is an important cause of diarrhea in humans and several animal species. Prostaglandins play a central role in regulating intestinal fluid secretion in animal models of cryptosporidiosis, but their cellular sources and mechanisms of induction are unclear. Here, we show that C. parvum infection directly activates prostaglandin H synthase 2 expression and prostaglandin E2 and F2alpha production in human intestinal epithelial cells.

* Corresponding author. Mailing address: University of California, San Diego, Department of Medicine 0623D, 9500 Gilman Dr., La Jolla, CA 92093-0623. Phone: (619) 534 0683. Fax: (619) 534 5691. E-mail: leckmann{at}ucsd.edu.

dagger Present address: Institute of Child Health, University of Birmingham, Birmingham B16 8ET, United Kingdom.




This article has been cited by other articles:

  • Pantenburg, B., Dann, S. M., Wang, H.-C., Robinson, P., Castellanos-Gonzalez, A., Lewis, D. E., White, A. C. Jr. (2008). Intestinal Immune Response to Human Cryptosporidium sp. Infection. Infect. Immun. 76: 23-29 [Full Text]  
  • Gookin, J. L., Duckett, L. L., Armstrong, M. U., Stauffer, S. H., Finnegan, C. P., Murtaugh, M. P., Argenzio, R. A. (2004). Nitric oxide synthase stimulates prostaglandin synthesis and barrier function in C. parvum-infected porcine ileum. Am. J. Physiol. Gastrointest. Liver Physiol. 287: G571-G581 [Abstract] [Full Text]  
  • Zaalouk, T. K., Bajaj-Elliott, M., George, J. T., McDonald, V. (2004). Differential Regulation of {beta}-Defensin Gene Expression during Cryptosporidium parvum Infection. Infect. Immun. 72: 2772-2779 [Abstract] [Full Text]  
  • Berkes, J, Viswanathan, V K, Savkovic, S D, Hecht, G (2003). Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation. Gut 52: 439-451 [Abstract] [Full Text]  
  • Cole, J., Blikslager, A., Hunt, E., Gookin, J., Argenzio, R. (2003). Cyclooxygenase blockade and exogenous glutamine enhance sodium absorption in infected bovine ileum. Am. J. Physiol. Gastrointest. Liver Physiol. 284: G516-G524 [Abstract] [Full Text]  
  • Chen, X.-M., Keithly, J. S., Paya, C. V., LaRusso, N. F. (2002). Cryptosporidiosis. NEJM 346: 1723-1731 [Full Text]  
  • Blikslager, A., Hunt, E., Guerrant, R., Rhoads, M., Argenzio, R. (2001). Glutamine transporter in crypts compensates for loss of villus absorption in bovine cryptosporidiosis. Am. J. Physiol. Gastrointest. Liver Physiol. 281: G645-G653 [Abstract] [Full Text]  
  • Stenson, W. F., Zhang, Z., Riehl, T., Stanley, S. L. Jr. (2001). Amebic Infection in the Human Colon Induces Cyclooxygenase-2. Infect. Immun. 69: 3382-3388 [Abstract] [Full Text]  
  • Laurent, F., Mancassola, R., Lacroix, S., Menezes, R., Naciri, M. (2001). Analysis of Chicken Mucosal Immune Response to Eimeria tenella and Eimeria maxima Infection by Quantitative Reverse Transcription-PCR. Infect. Immun. 69: 2527-2534 [Abstract] [Full Text]  
  • Robinson, P., Okhuysen, P. C., Chappell, C. L., Lewis, D. E., Shahab, I., Janecki, A., White, A. C. Jr. (2001). Expression of Tumor Necrosis Factor Alpha and Interleukin 1{beta} in Jejuna of Volunteers after Experimental Challenge with Cryptosporidium parvum Correlates with Exposure but Not with Symptoms. Infect. Immun. 69: 1172-1174 [Abstract] [Full Text]  
  • Kasper, L. H., Buzoni-Gatel, D. (2001). Ups and Downs of Mucosal Cellular Immunity against Protozoan Parasites. Infect. Immun. 69: 1-8 [Full Text]  
  • McCole, D. F., Eckmann, L., Laurent, F., Kagnoff, M. F. (2000). Intestinal Epithelial Cell Apoptosis following Cryptosporidium parvum Infection. Infect. Immun. 68: 1710-1713 [Abstract] [Full Text]  
  • O'Neil, D. A., Porter, E. M., Elewaut, D., Anderson, G. M., Eckmann, L., Ganz, T., Kagnoff, M. F. (1999). Expression and Regulation of the Human {beta}-Defensins hBD-1 and hBD-2 in Intestinal Epithelium. J. Immunol. 163: 6718-6724 [Abstract] [Full Text]  
  • Clark, D. P. (1999). New Insights into Human Cryptosporidiosis. Clin. Microbiol. Rev. 12: 554-563 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»