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Infect Immun, April 1998, p. 1791-1794, Vol. 66, No. 4
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Binding to Human Extracellular Matrix by Neisseria meningitidis

Thomas Eberhard,1 Ritva Virkola,2 Timo Korhonen,2 Göran Kronvall,1 and Måns Ullberg1,*

Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Hospital, Stockholm, Sweden,1 and Department of Biosciences, Division of General Microbiology, University of Helsinki, Helsinki, Finland2

Received 7 April 1997/Returned for modification 28 May 1997/Accepted 27 January 1998

Adhesion of Neisseria meningitidis strains to extracellular matrix (ECM) and purified matrix components was examined. Most strains bound to subendothelial ECM as well as to immobilized fibronectin and types I, III, and V collagen. Strains from healthy carriers adhered significantly better than isolates from patients. The binding site was localized to the central 75-kDa cell-binding domain of the fibronectin molecule. This domain has not been described previously to interact with bacterial structures.

* Corresponding author. Mailing address: Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Hospital, Stockholm S-171 76, Sweden. Phone: 46-8-517 749 20. Fax: 46-8-30 80 99. E-mail: mans{at}mb.ks.se.




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