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Infect Immun, April 1998, p. 1795-1799, Vol. 66, No. 4
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Distribution of Protein Kinase C Isoforms after Infection of Macrophages with Leishmania major

Sabine Pingel,1,2 Zhi-En Wang,1,2,3 and Richard M. Locksley1,2,3,*

Departments of Medicine1 and Microbiology/Immunology2 and Howard Hughes Medical Institute,3 University of California San Francisco, San Francisco, California 94143-0654

Received 1 July 1997/Returned for modification 1 September 1997/Accepted 19 December 1997

We characterized the effects of Leishmania infection on activation-induced translocation of protein kinase C (PKC) isoforms in murine bone marrow-derived macrophages. Although PKC-dependent gene expression was attenuated by infection, the distribution and translocation of PKC isoforms were unaffected. However, subsequent dissociation from membranes was substantially delayed for some isoforms, particularly PKCbeta .

* Corresponding author. Mailing address: UCSF, Box 0654, C-443, 521 Parnassus Ave., San Francisco, CA 94143-0654. Phone: (415) 476-9362. Fax: (415) 476-9364. E-mail: rich_locksley{at}quickmail.ucsf.edu.




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