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Infect Immun, April 1998, p. 1800-1802, Vol. 66, No. 4
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Increased Leptin Expression in Mice with Bacterial Peritonitis is Partially Regulated by Tumor Necrosis Factor Alpha

Armin K. Moshyedi,1 Michael D. Josephs,1 Eddie K. Abdalla,1 Sally L. D. MacKay,1 Carl K. Edwards III,2 Edward M. Copeland III,1 and Lyle L. Moldawer1,*

Department of Surgery, University of Florida College of Medicine, Gainesville, Florida 32610,1 and Amgen, Inc., Boulder, Colorado 803012

Received 29 September 1997/Returned for modification 11 November 1997/Accepted 21 January 1998

Plasma leptin and ob gene mRNA levels were increased in mice following bacterial peritonitis, and blocking an endogenous tumor necrosis factor alpha (TNF-alpha ) response blunted the increase. However, plasma leptin concentrations did not correlate with the associated anorexia. We conclude that leptin expression is under partial regulatory control of TNF-alpha in peritonitis, but the anorexia is not dependent on increased leptin production.

* Corresponding author. Mailing address: Department of Surgery, P.O. Box 100286, Gainesville, FL 32610. Phone: (352) 395-0494. Fax: (352) 395-0676. E-mail: moldawer{at}surgery.ufl.edu.




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