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Infect Immun, April 1998, p. 1803-1805, Vol. 66, No. 4
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Granulocytic Ehrlichiosis in Tick-Immune Guinea Pigs

Subrata Das,1 Kathleen Deponte,1 Nancy L. Marcantonio,1 Jacob W. Ijdo,1 Emir Hodzic,2 Paula Katavolos,3 Stephen W. Barthold,2 Sam R. Telford III,3 Fred S. Kantor,1 and Erol Fikrig1,*

Department of Internal Medicine, Yale University, New Haven, Connecticut1; The Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California, Davis, Davis, California2; and Department of Tropical Public Health, Harvard University School of Public Health, Boston, Massachusetts3

Received 18 September 1997/Returned for modification 10 November 1997/Accepted 12 January 1998

We investigated whether Ixodes scapularis-mediated host immunity interrupts transmission of the agent of human granulocytic ehrlichiosis (aoHGE) to guinea pigs. Ticks infected with aoHGE readily transmitted aoHGE to tick-immune guinea pigs, despite incomplete tick engorgement and host attachment. Although tick immunity can prevent Lyme borreliosis, protection is not afforded against granulocytic ehrlichiosis.

* Corresponding author. Mailing address: Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520-8031. Phone: (203) 785-2454. Fax: (203) 785-7053. E-mail: erol.fikrig{at}yale.edu.




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