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Infect Immun, May 1998, p. 2093-2098, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Reduced Response to Multiple Vaccines Sharing Common Protein Epitopes That Are Administered Simultaneously to Infants

Ron Dagan,1,2,* Juhani Eskola,3 Claude Leclerc,4 and Odile Leroy5

Pediatric Infectious Disease Unit, Soroka University Medical Center,1 and Faculty of Health Sciences, Ben-Gurion University of the Negev,2 Beer-Sheva, Israel; National Public Health Institute, Helsinki, Finland3; and Department of Immunology, Institut Pasteur, Paris,4 and Pasteur Mérieux Connaught, Marnes la Coquette,5 France

Received 13 October 1997/Returned for modification 21 November 1997/Accepted 5 February 1998

The plethora of newly discovered vaccines implies that, in the future, many vaccines will have to be administered simultaneously to infants. We examined the potential interference with the immune response of several coadministered vaccines containing the same protein component, namely, tetanus toxoid (TT). Infants simultaneously receiving a tetravalent pneumococcal vaccine conjugated to TT (PncT) and a diphtheria-tetanus-pertussis-poliovirus-Haemophilus influenzae type b-tetanus conjugate vaccine showed significantly lower anti-H. influenzae type b polysaccharide (polyribosylribitol phosphate [PRP]) antibody concentrations than those receiving either a tetravalent pneumococcal vaccine conjugated to diphtheria toxoid or placebo. A dose range study showed that anti-PRP antibody concentrations were inversely related to the TT content of the PncT vaccines administered in infancy. Postimmunization antitetanus antibody concentrations were also affected adversely as the TT content of the coadministered vaccines was increased. This phenomenon, which we believe derives from interference by a common protein carrier, should be taken into account when the introduction of an immunization program including multiple conjugate vaccines is considered.

* Corresponding author. Mailing address: Pediatric Infectious Disease Unit, Soroka University Medical Center, P.O. Box 151, Beer-Sheva 84101, Israel. Phone: (972-7) 640-0547. Fax: (972-7) 623-2334. E-mail: rdagan{at}bgumail.bgu.ac.il.

Infect Immun, May 1998, p. 2093-2098, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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