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Infect Immun, May 1998, p. 2128-2134, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Kinetics of Infection and Effects on Placental Cell Populations in a Murine Model of Chlamydia psittaci-Induced Abortion

Antonio J. Buendía,1,* Joaquín Sánchez,2 María C. Martínez,2 Paulina Cámara,2 Jose A. Navarro,2 Annie Rodolakis,3 and Jesus Salinas1

Departamento de Patología Animal (Microbiología e Inmunología)1 and Departamento de Histología y Anatomía Patológica,2 Facultad de Veterinaria, Universidad de Murcia, 30100 Murcia, Spain, and Pathologie Infectiouse et Immunologie, Institut National de la Recherche Agronomique, 37380 Nouzilly, France3

Received 14 November 1997/Returned for modification 30 December 1997/Accepted 13 February 1998

The anatomical progression of chlamydial infection was studied in different areas of the placenta, using a mouse model and two inoculation times: early pregnancy (day 7, group A) and midpregnancy (day 11, group B). The first population cells affected were decidual cells and neutrophils located just at the limits of the maternal and fetal placenta. The following invaded area was the layer of giant cells. Complete colonization of the maternal placenta occurred after day 15 of pregnancy independently of the inoculation time, the metrial gland being the last area to be invaded; numerous granulated metrial gland (GMG) cells were infected. Finally, chlamydial inclusions were observed in labyrinthine trophoblastic cells from day 18 of pregnancy onward. Since no fetal damage was observed, it seems that an indirect mechanism involving the lysis of GMG cells and neutrophil infiltration of the decidua and metrial gland may be the pathogenic mechanism that leads to abortion.

* Corresponding author. Mailing address: Departamento Patología Animal (Microbiología e Inmunología), Facultad de Veterinaria, Universidad de Murcia, Campus de Espinardo, Murcia 30100, Spain. Phone: (34) 68 364810. Fax: (34) 68 364147. E-mail: abuendia{at}fcu.um.es.

Infect Immun, May 1998, p. 2128-2134, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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