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Infect Immun, May 1998, p. 2342-2345, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Protection against Lethal Murine Coccidioidomycosis by a Soluble Vaccine from Spherules

C. Roger Zimmermann,1,* Suzanne M. Johnson,1 Gregory W. Martens,1 Andrew G. White,1 Barbara L. Zimmer,1,2 and Demosthenes Pappagianis1

Department of Medical Microbiology and Immunology1 and Department of Dermatology,2 School of Medicine, University of California, Davis, California 95616

Received 4 September 1997/Returned for modification 10 October 1997/Accepted 2 January 1998

The formaldehyde-killed, whole-spherule vaccine, which is protective against lethal challenge of laboratory animals with Coccidioides immitis, was fractionated. It yielded a soluble, multicomponent, subcellular fraction termed the 27K vaccine. This vaccine, when it was accompanied by adjuvant, protected mice against lethal intranasal and intravenous challenge with C. immitis.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616. Phone: (916) 752-7214. Fax: (916) 752-8692. E-mail: crzimmermann{at}ucdavis.edu.

Infect Immun, May 1998, p. 2342-2345, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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