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Infect Immun, May 1998, p. 2352-2355, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Chlamydia trachomatis Infection of Human Mesothelial Cells Alters Proinflammatory, Procoagulant, and Fibrinolytic Responses

Mireille van Westreenen,1,* Apollo Pronk,1 Rob J. A. Diepersloot,2 Philip G. de Groot,3 and Piet Leguit1

Departments of Surgery1 and Microbiology,2 Diakonessen Hospital, and Department of Hematology, The University Hospital Utrecht,3 Utrecht, The Netherlands

Received 25 August 1997/Returned for modification 9 October 1997/Accepted 2 February 1998

In this study we demonstrate the capability of Chlamydia trachomatis to infect cultured human mesothelial cell (MC) monolayers and to induce the production of the proinflammatory cytokines interleukin 1beta (IL-1beta ) and IL-8. Seventy-two hours after initial infection, both the procoagulant activity of MC and the activity of the fibrinolytic inhibitor (plasminogen activator inhibitor 1) in the supernatants were enhanced. These findings support the hypothesis that provoked proinflammatory responses contribute to the development of complications after chlamydial infection.

* Corresponding author. Mailing address: Department of Surgery, Diakonessen Hospital, Bosboomstraat 1, 3582 KE Utrecht, The Netherlands. Phone: 31-30-2 566 518. Fax: 31-30-2 566 695. E-mail: mmldiak{at}wxs.nl.

Infect Immun, May 1998, p. 2352-2355, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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