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Infect Immun, May 1998, p. 2365-2367, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Lipoprotein(a) Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor Alpha Production by Human Mononuclear Cells

Mihai G. Netea, Natasja de Bont, Pierre N. M. Demacker, Bart Jan Kullberg, Liesbeth E. H. Jacobs, Trees J. G. Verver-Jansen, Anton F. H. Stalenhoef, and Jos W. M. Van der Meer*

Division of General Internal Medicine, Department of Medicine, University Hospital Nijmegen, 6500 HB Nijmegen, The Netherlands

Received 13 November 1997/Returned for modification 15 December 1997/Accepted 3 February 1998

Lipoproteins can bind lipopolysaccharide (LPS) and decrease LPS-stimulated cytokine production. Lipoprotein(a) [Lp(a)] was as potent as low-density lipoproteins (LDL) in inhibiting LPS-stimulated tumor necrosis factor synthesis by human mononuclear cells. The kinetics of LPS inhibition by Lp(a) was similar to that of LDL. This suggests that circulating Lp(a) may be an important factor determining the amplitude of the response to LPS in humans.

* Corresponding author. Mailing address: Department of Medicine (541), University Hospital Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Phone: 31-24-3614763/3614782. Fax: 31-24-3541734. E-mail: j.vandermeer{at}aig.azn.nl.

Infect Immun, May 1998, p. 2365-2367, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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