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Infect Immun, May 1998, p. 2393-2398, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

gamma delta + T Cells Preferentially Respond to Live Rather than Killed Malaria Parasites

Martin Waterfall, Antony Black, and Eleanor Riley*

Institute of Cell, Animal and Population Biology, Ashworth Laboratories, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom

Received 12 November 1997/Returned for modification 17 December 1997/Accepted 2 March 1998

We have compared the in vitro responses of peripheral blood T cells from malaria-unexposed donors to live Plasmodium falciparum schizonts, freeze-thawed schizont extracts (P. falciparum schizont extracts [PfSE]), and parasite culture supernatants. We show that the cells responding to PfSE and parasite culture supernatants are predominantly CD4+ TCRalpha beta + while in the presence of live schizonts there is an additional activation of TCRgamma delta + cells. Activation of TCRgamma delta + cells in response to PfSE was seen only when irradiated autologous feeder cells or recombinant interleukin-2 (IL-2) was added to the cultures. Live schizonts but not PfSE induced significant IL-2 production in vitro in the first 5 days after stimulation, suggesting that induction of early IL-2 by live parasites may contribute to the marked activation of the TCRgamma delta + population.

* Corresponding author. Mailing address: Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, West Mains Rd., Edinburgh EH9 3JT, United Kingdom. Phone: 0131-650-5540. Fax: 0131-667-3210. E-mail: e.riley{at}ed.ac.uk.

Infect Immun, May 1998, p. 2393-2398, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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