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Infect Immun, June 1998, p. 2814-2817, Vol. 66, No. 6
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Listeria monocytogenes-Infected Hepatocytes Are Targets of Major Histocompatibility Complex Class Ib-Restricted Antilisterial Cytotoxic T Lymphocytes

H. G. Archie Bouwer,1,* Ailin Bai,2,3 James Forman,2 Stephen H. Gregory,4 Edward J. Wing,4 Ronald A. Barry,1 and David J. Hinrichs1

Immunology Research, VA Medical Center, and Earle A. Chiles Research Institute, Portland, Oregon1; Department of Microbiology2 and Immunology Graduate Program,3 University of Texas Southwestern Medical Center at Dallas, Dallas, Texas; and Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania4

Received 5 December 1997/Returned for modification 17 February 1998/Accepted 16 March 1998

Subclinical infection of BALB/c mice with the intracellular bacterial pathogen Listeria monocytogenes results in the development of protective antilisterial immunity. L. monocytogenes can infect hepatocytes, and antilisterial cytotoxic T lymphocytes (CTL) lyse Listeria-infected hepatocytes in a major histocompatibility complex (MHC) class Ia-restricted manner. It remained to be determined whether L. monocytogenes-infected hepatocytes are susceptible to MHC class Ib-restricted cytolysis. In this study, we showed that hepatocytes express MHC class Ib molecule Qa-1b mRNA and protein. We further showed that Listeria-infected hepatocytes are susceptible to MHC class Ib-restricted cytolysis, since C57BL/6-derived Listeria-infected hepatocytes were lysed by BALB/c-derived antilisterial CTL. These results establish that Listeria-infected hepatocytes are susceptible to cytolysis by MHC class Ib restricted Listeria-specific CTL.

* Corresponding author. Mailing address: Immunology Research 151-R, VA Medical Center, 3710 S.W. U.S. Veterans Hospital Rd., Portland, OR 97201. Phone: (503) 721-7840. Fax: (503) 273-5135. E-mail: bouwera{at}ohsu.edu.

Infect Immun, June 1998, p. 2814-2817, Vol. 66, No. 6
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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