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Infect Immun, June 1998, p. 2976-2979, Vol. 66, No. 6
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

LcrG is Required for Efficient Translocation of Yersinia Yop Effector Proteins into Eukaryotic Cells

Mahfuzur R. Sarker,dagger Marie-Paule Sory, Aoife P. Boyd, Maite Iriarte, and Guy R. Cornelis*

Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology, and Faculté de Médecine, Université Catholique de Louvain, B-1200 Brussels, Belgium

Received 11 November 1997/Returned for modification 31 December 1997/Accepted 2 February 1998

Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrG mutant is severely impaired in the translocation of YopE, YopH, YopM, YpkA/YopO, and YopP into eukaryotic cells. LcrG is thus required for efficient internalization of all the known Yop effectors.

* Corresponding author. Mailing address: Microbial Pathogenesis Unit, Université de Louvain, Avenue Hippocrate, 74, UCL 74.49, B-1200 Brussels, Belgium. Phone: (32)(2)764 74 49. Fax: (32)(2)764 74 98. E-mail: cornelis{at}mipa.ucl.ac.be.

dagger Present address: Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.

Infect Immun, June 1998, p. 2976-2979, Vol. 66, No. 6
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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