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Infect Immun, June 1998, p. 2991-2995, Vol. 66, No. 6
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Acute and Chronic Phases of Toxoplasma gondii Infection in Mice Modulate the Host Immune Responses

T. D. Nguyen,1 G. Bigaignon,1,* J. Van Broeck,2 M. Vercammen,3 T. N. Nguyen,1 M. Delmee,1 M. Turneer,3 S. F. Wolf,4 and J. P. Coutelier2

Microbiology Unit, Cliniques Universitaires Saint-Luc,1 and Experimental Medicine Unit, ICP, Catholic University of Louvain,2 1200 Brussels, and Institut Pasteur, 1180 Brussels,3 Belgium, and Genetics Institute, Inc., Cambridge, Massachusetts 021404

Received 1 December 1997/Returned for modification 5 January 1998/Accepted 6 March 1998

Murine antibody responses to soluble proteins are generally restricted to the immunoglobulin G1 (IgG1) isotype. When mice were infected with Toxoplasma gondii Beverley and concomitantly immunized with a soluble unrelated protein antigen, a modification in the isotypic distribution of antibodies directed against this nonparasite antigen was observed, with a preferential production of IgG2a. Interestingly, when mice were immunized with a soluble protein antigen during the chronic phase (day 40) of infection with T. gondii Beverley, a similar modification in the isotypic distribution of antiprotein antibodies was observed.

* Corresponding author. Mailing address: Cliniques Universitaires Saint-Luc, Avenue Hippocrate, 10, B-1200 Brussels, Belgium. Phone: 32-2-764 17 50. Fax: 32-2-7649310. E-mail: bigaignon{at}lewsun.md.ucl.ac.be.

Infect Immun, June 1998, p. 2991-2995, Vol. 66, No. 6
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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