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Infect Immun, June 1998, p. 3012-3016, Vol. 66, No. 6
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Clearance of Shigella flexneri Infection Occurs through a Nitric Oxide-Independent Mechanism

Sing Sing Way and Marcia B. Goldberg*

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461

Received 31 October 1997/Returned for modification 6 January 1998/Accepted 27 March 1998

Nitric oxide (NO) generated by gamma interferon (IFN-gamma ) activation of macrophages mediates the killing of many intracellular pathogens. IFN-gamma is essential to innate resistance to Shigella flexneri infection. We demonstrate that NO is produced following S. flexneri infection both in mice and in activated cells in vitro and that while it is able to kill S. flexneri in a cell-free system, it is not required for clearance of S. flexneri in either infected mice or in activated cells in vitro.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461. Phone: (718) 430-2118. Fax: (718) 430-8711. E-mail: mgoldber{at}aecom.yu.edu.

Infect Immun, June 1998, p. 3012-3016, Vol. 66, No. 6
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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