This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lewis, L. A.
Right arrow Articles by Dyer, D. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lewis, L. A.
Right arrow Articles by Dyer, D. W.

 Previous Article  |  Next Article 

Infect Immun, June 1998, p. 3017-3023, Vol. 66, No. 6
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Identification and Molecular Analysis of lbpBA, Which Encodes the Two-Component Meningococcal Lactoferrin Receptor

L. A. Lewis,1,* K. Rohde,1 M. Gipson,1 B. Behrens,1 E. Gray,1 S. I. Toth,2 B. A. Roe,2 and D. W. Dyer1

Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73103,1 and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 730192

Received 10 October 1997/Returned for modification 30 December 1997/Accepted 2 March 1998

We identified lbpB, encoding the lipoprotein component of the meningococcal lactoferrin receptor. An LbpB mutant was unable to acquire Fe from lactoferrin and exhibits decreased surface binding to lactoferrin. Primer extension and reverse transcription-PCR analysis indicate that lbpB and lbpA are cotranscribed on a polycistronic Fe-repressible mRNA.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190. Phone: (405) 271-1201. Fax: (405) 271-3117. E-mail: llewis{at}rex.uokhsc.edu.

Infect Immun, June 1998, p. 3017-3023, Vol. 66, No. 6
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Rohde, K. H., Dyer, D. W. (2004). Analysis of Haptoglobin and Hemoglobin-Haptoglobin Interactions with the Neisseria meningitidis TonB-Dependent Receptor HpuAB by Flow Cytometry. Infect. Immun. 72: 2494-2506 [Abstract] [Full Text]  
  • Perkins-Balding, D., Ratliff-Griffin, M., Stojiljkovic, I. (2004). Iron Transport Systems in Neisseria meningitidis. Microbiol. Mol. Biol. Rev. 68: 154-171 [Abstract] [Full Text]  
  • Wong, H., Schryvers, A. B. (2003). Bacterial lactoferrin-binding protein A binds to both domains of the human lactoferrin C-lobe. Microbiology 149: 1729-1737 [Abstract] [Full Text]  
  • Ronpirin, C., Jerse, A. E., Cornelissen, C. N. (2001). Gonococcal Genes Encoding Transferrin-Binding Proteins A and B Are Arranged in a Bicistronic Operon but Are Subject to Differential Expression. Infect. Immun. 69: 6336-6347 [Abstract] [Full Text]  
  • Desai, P. J., Garges, E., Genco, C. A. (2000). Pathogenic Neisseriae Can Use Hemoglobin, Transferrin, and Lactoferrin Independently of the tonB Locus. J. Bacteriol. 182: 5586-5591 [Abstract] [Full Text]  
  • Hopper, S., Wilbur, J. S., Vasquez, B. L., Larson, J., Clary, S., Mehr, I. J., Seifert, H. S., So, M. (2000). Isolation of Neisseria gonorrhoeae Mutants That Show Enhanced Trafficking across Polarized T84 Epithelial Monolayers. Infect. Immun. 68: 896-905 [Abstract] [Full Text]  
  • Yu, R.-h., Bonnah, R. A., Ainsworth, S., Schryvers, A. B. (1999). Analysis of the Immunological Responses to Transferrin and Lactoferrin Receptor Proteins from Moraxella catarrhalis. Infect. Immun. 67: 3793-3799 [Abstract] [Full Text]  
  • van der Ende, A., Hopman, C. T. P., Dankert, J. (1999). Deletion of porA by Recombination between Clusters of Repetitive Extragenic Palindromic Sequences in Neisseria meningitidis. Infect. Immun. 67: 2928-2934 [Abstract] [Full Text]  
  • Carson, S. D. B., Klebba, P. E., Newton, S. M. C., Sparling, P. F. (1999). Ferric Enterobactin Binding and Utilization by Neisseria gonorrhoeae. J. Bacteriol. 181: 2895-2901 [Abstract] [Full Text]  
  • Biswas, G. D., Anderson, J. E., Chen, C.-J., Cornelissen, C. N., Sparling, P. F. (1999). Identification and Functional Characterization of the Neisseria gonorrhoeae lbpB Gene Product. Infect. Immun. 67: 455-459 [Abstract] [Full Text]  
  • Lewis, L. A., Sung, M.-H., Gipson, M., Hartman, K., Dyer, D. W. (1998). Transport of Intact Porphyrin by HpuAB, the Hemoglobin-Haptoglobin Utilization System of Neisseria meningitidis. J. Bacteriol. 180: 6043-6047 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»