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Infect Immun, June 1998, p. 3017-3023, Vol. 66, No. 6
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Identification and Molecular Analysis of lbpBA, Which Encodes the Two-Component Meningococcal Lactoferrin Receptor

L. A. Lewis,1,* K. Rohde,1 M. Gipson,1 B. Behrens,1 E. Gray,1 S. I. Toth,2 B. A. Roe,2 and D. W. Dyer1

Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73103,1 and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 730192

Received 10 October 1997/Returned for modification 30 December 1997/Accepted 2 March 1998

We identified lbpB, encoding the lipoprotein component of the meningococcal lactoferrin receptor. An LbpB mutant was unable to acquire Fe from lactoferrin and exhibits decreased surface binding to lactoferrin. Primer extension and reverse transcription-PCR analysis indicate that lbpB and lbpA are cotranscribed on a polycistronic Fe-repressible mRNA.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190. Phone: (405) 271-1201. Fax: (405) 271-3117. E-mail: llewis{at}rex.uokhsc.edu.

Infect Immun, June 1998, p. 3017-3023, Vol. 66, No. 6
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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