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Infect Immun, June 1998, p. 3024-3027, Vol. 66, No. 6
0019-9567/98/$00.00+0

Enhanced Levels of Staphylococcus aureus Stress Protein GroEL and DnaK Homologs Early in Infection of Human Epithelial Cells

M. Walid Qoronfleh,1,* Carol A. Bortner,2 Paul Schwartzberg,3 and Brian J. Wilkinson4

Structural Biochemistry Program, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-12011; Department of Research, York Hospital, York, Pennsylvania 17405-71982; Department of Microbiology, Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania 19131-16963; and Microbiology Group, Department of Biological Sciences, Illinois State University, Normal, Illinois 61790-41204

Received 13 January 1998/Returned for modification 6 March 1998/Accepted 31 March 1998

Antibodies to Staphylococcus aureus heat shock proteins (Hsps) are present in the sera of patients with S. aureus endocarditis (M. W. Qoronfleh, W. Weraarchakul, and B. J. Wilkinson, Infect. Immun. 61:1567-1570, 1993). Although these proteins are immunogenic, their role in infection has not been established. We developed a cell culture system as a model to examine the potential involvement of staphylococcal Hsps in the initial events of infection. This study supports a model in which a clinical endocarditis isolate responds to host cell signals by selectively regulating the synthesis of numerous proteins, including the stress proteins Hsp60 (GroEL homolog) and Hsp70 (DnaK homolog) and a unique 58-kDa protein.

* Corresponding author. Mailing address: SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center (NCI-FCRDC), Structural Biochemistry Program (SBP), Bldg. 320, P.O. Box B, Frederick, MD 21702-1201. Phone: (301) 846-1996. Fax: (301) 846-6875. E-mail: ooronfle{at}ncifcrf.gov.

Infect Immun, June 1998, p. 3024-3027, Vol. 66, No. 6
0019-9567/98/$00.00+0


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