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Infect Immun, July 1998, p. 3164-3169, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Role of Alveolar Macrophages in Initiation and Regulation of Inflammation in Pseudomonas aeruginosa Pneumonia

Kunihiko Kooguchi,1,* Satoru Hashimoto,1 Atsuko Kobayashi,1 Yoshihiro Kitamura,1 Ichidai Kudoh,2 Jeanine Wiener-Kronish,3 and Teiji Sawa3

Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto,1 and Department of Anesthesiology, Yokohama City University School of Medicine, Kanagawa,2 Japan, and Department of Anesthesiology, University of California San Francisco, San Francisco, California3

Received 1 December 1997/Returned for modification 10 February 1998/Accepted 23 April 1998

To evaluate the role of alveolar macrophages (AMs) in acute Pseudomonas aeruginosa pneumonia in mice, AMs were depleted by aerosol inhalation of liposomes containing clodronate disodium. AM-depleted mice were then intratracheally infected with 5 × 105 CFU of P. aeruginosa. In addition to monitoring neutrophil recruitment and chemokine releases, lung injury was evaluated soon after infection (8 h) and at a later time (48 h). At 8 h, depletion of AMs reduced neutrophil recruitment, chemokine release, and lung injury. At 48 h, however, depletion of AMs decreased bacterial clearance and resulted in delayed movement of neutrophils from the site of inflammation with aggravated lung injury. With instillation of 5 × 107 CFU of bacteria, AM-depleted mice showed low mortality within 24 h of infection but high mortality at a later time, in contrast to non-AM-depleted mice. These results demonstrate that depletion of AMs has beneficial early effects but deleterious late effects on lung injury and survival in cases of P. aeruginosa pneumonia.

* Corresponding author. Mailing address: Department of Anesthesiology, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-0841, Japan. Phone: 81 75 251 5633. Fax: 81 75 251 5843. E-mail: kobi{at}koto.kpu-m.ac.jp.

Infect Immun, July 1998, p. 3164-3169, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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  • Restrepo, C. I., Dong, Q., Savov, J., Mariencheck, W. I., Wright, J. R. (1999). Surfactant Protein D Stimulates Phagocytosis of Pseudomonas aeruginosa by Alveolar Macrophages. Am. J. Respir. Cell Mol. Bio. 21: 576-585 [Abstract] [Full Text]  
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