This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Everest, P.
Right arrow Articles by Dougan, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Everest, P.
Right arrow Articles by Dougan, G.

 Previous Article  |  Next Article 

Infect Immun, July 1998, p. 3355-3364, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Susceptibility to Salmonella typhimurium Infection and Effectiveness of Vaccination in Mice Deficient in the Tumor Necrosis Factor Alpha p55 Receptor

Paul Everest, Mark Roberts,dagger and Gordon Dougan*

Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AZ, United Kingdom

Received 10 September 1997/Returned for modification 17 November 1997/Accepted 22 April 1998

Mice defective in the ability to produce the tumor necrosis factor alpha p55 receptor (TNFalpha p55R) were orally challenged with a number of Salmonella typhimurium HWSH derivatives that differ in virulence. In comparison to TNFalpha p55R+/+ mice, TNFalpha p55R-/- mice succumbed earlier to challenge with wild-type S. typhimurium HWSH and S. typhimurium HWSH purE. In contrast, TNFalpha p55R-/- mice were able to control an S. typhimurium HWSH aroA challenge, although greater numbers of Salmonella organisms were present in the tissues for a longer time period than was observed with TNFalpha p55R+/+ mice. Vaccination of normal and TNFalpha p55R knockout animals with S. typhimurium HWSH aroA showed that TNFalpha p55R-/- mice, unlike TNFalpha p55R+/+ mice, were not protected against a virulent S. typhimurium HWSH challenge. Splenocytes from TNFalpha p55R-/- mice exhibited a reduced ability to proliferate in the presence of S. typhimurium antigen compared to TNFalpha p55R+/+ mice. Thus, TNFalpha p55R is essential for controlling Salmonella growth in tissues and for recall of immunity in murine salmonellosis.

* Corresponding author. Mailing address: Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AZ, United Kingdom. Phone: 44 171 594 5254. Fax: 44 171 594 5255. E-mail: g.dougan{at}ic.ac.uk.

dagger Present address: Department of Veterinary Pathology, Glasgow University Veterinary School, Glasgow G61 1QH, United Kingdom.

Infect Immun, July 1998, p. 3355-3364, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Torii, I., Oka, S., Hotomi, M., Benjamin, W. H. Jr, Takai, T., Kearney, J. F., Briles, D. E., Kubagawa, H. (2008). PIR-B-Deficient Mice Are Susceptible to Salmonella Infection. J. Immunol. 181: 4229-4239 [Abstract] [Full Text]  
  • Rotta, G., Matteoli, G., Mazzini, E., Nuciforo, P., Colombo, M. P., Rescigno, M. (2008). Contrasting roles of SPARC-related granuloma in bacterial containment and in the induction of anti-Salmonella typhimurium immunity. JEM 205: 657-667 [Abstract] [Full Text]  
  • Medina, F. A., de Almeida, C. J., Dew, E., Li, J., Bonuccelli, G., Williams, T. M., Cohen, A. W., Pestell, R. G., Frank, P. G., Tanowitz, H. B., Lisanti, M. P. (2006). Caveolin-1-Deficient Mice Show Defects in Innate Immunity and Inflammatory Immune Response during Salmonella enterica Serovar Typhimurium Infection. Infect. Immun. 74: 6665-6674 [Abstract] [Full Text]  
  • al-Ramadi, B. K., Fernandez-Cabezudo, M. J., Ullah, A., El-Hasasna, H., Flavell, R. A. (2006). CD154 Is Essential for Protective Immunity in Experimental Salmonella Infection: Evidence for a Dual Role in Innate and Adaptive Immune Responses. J. Immunol. 176: 496-506 [Abstract] [Full Text]  
  • Rhee, S. J., Walker, W. A., Cherayil, B. J. (2005). Developmentally Regulated Intestinal Expression of IFN-{gamma} and Its Target Genes and the Age-Specific Response to Enteric Salmonella Infection. J. Immunol. 175: 1127-1136 [Abstract] [Full Text]  
  • van Diepen, A., van de Gevel, J. S., Koudijs, M. M., Ossendorp, F., Beekhuizen, H., Janssen, R., van Dissel, J. T. (2005). Gamma Irradiation or CD4+-T-Cell Depletion Causes Reactivation of Latent Salmonella enterica Serovar Typhimurium Infection in C3H/HeN Mice. Infect. Immun. 73: 2857-2862 [Abstract] [Full Text]  
  • Haraga, A., Miller, S. I. (2003). A Salmonella enterica Serovar Typhimurium Translocated Leucine-Rich Repeat Effector Protein Inhibits NF-{kappa}B-Dependent Gene Expression. Infect. Immun. 71: 4052-4058 [Abstract] [Full Text]  
  • Raupach, B., Kurth, N., Pfeffer, K., Kaufmann, S. H. E. (2003). Salmonella typhimurium Strains Carrying Independent Mutations Display Similar Virulence Phenotypes Yet Are Controlled by Distinct Host Defense Mechanisms. J. Immunol. 170: 6133-6140 [Abstract] [Full Text]  
  • Kuprash, D. V., Alimzhanov, M. B., Tumanov, A. V., Grivennikov, S. I., Shakhov, A. N., Drutskaya, L. N., Marino, M. W., Turetskaya, R. L., Anderson, A. O., Rajewsky, K., Pfeffer, K., Nedospasov, S. A. (2002). Redundancy in Tumor Necrosis Factor (TNF) and Lymphotoxin (LT) Signaling In Vivo: Mice with Inactivation of the Entire TNF/LT Locus versus Single-Knockout Mice. Mol. Cell. Biol. 22: 8626-8634 [Abstract] [Full Text]  
  • Kirby, A. C., Yrlid, U., Wick, M. J. (2002). The Innate Immune Response Differs in Primary and Secondary Salmonella Infection. J. Immunol. 169: 4450-4459 [Abstract] [Full Text]  
  • Lehmann, J., Bellmann, S., Werner, C., Schroder, R., Schutze, N., Alber, G. (2001). IL-12p40-Dependent Agonistic Effects on the Development of Protective Innate and Adaptive Immunity Against Salmonella Enteritidis. J. Immunol. 167: 5304-5315 [Abstract] [Full Text]  
  • Heinrich, J.-M., Bernheiden, M., Minigo, G., Yang, K. K., Schutt, C., Mannel, D. N., Jack, R. S. (2001). The Essential Role of Lipopolysaccharide-Binding Protein in Protection of Mice Against a Peritoneal Salmonella Infection Involves the Rapid Induction of an Inflammatory Response. J. Immunol. 167: 1624-1628 [Abstract] [Full Text]  
  • Vázquez-Torres, A., Fantuzzi, G., Edwards, C. K. III, Dinarello, C. A., Fang, F. C. (2001). Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages. Proc. Natl. Acad. Sci. USA 10.1073/pnas.041618998v1 [Abstract] [Full Text]  
  • Li, C., Langhorne, J. (2000). Tumor Necrosis Factor Alpha p55 Receptor Is Important for Development of Memory Responses to Blood-Stage Malaria Infection. Infect. Immun. 68: 5724-5730 [Abstract] [Full Text]  
  • Mastroeni, P., Vazquez-Torres, A., Fang, F. C., Xu, Y., Khan, S., Hormaeche, C. E., Dougan, G. (2000). Antimicrobial Actions of the NADPH Phagocyte Oxidase and Inducible Nitric Oxide Synthase in Experimental Salmonellosis. II. Effects on Microbial Proliferation and Host Survival In Vivo. JEM 192: 237-248 [Abstract] [Full Text]  
  • Zhao, Y.-X., Lajoie, G., Zhang, H., Chiu, B., Payne, U., Inman, R. D. (2000). Tumor Necrosis Factor Receptor p55-Deficient Mice Respond to Acute Yersinia enterocolitica Infection with Less Apoptosis and More Effective Host Resistance. Infect. Immun. 68: 1243-1251 [Abstract] [Full Text]  
  • Ciacci-Woolwine, F., McDermott, P. F., Mizel, S. B. (1999). Induction of Cytokine Synthesis by Flagella from Gram-Negative Bacteria May Be Dependent on the Activation or Differentiation State of Human Monocytes. Infect. Immun. 67: 5176-5185 [Abstract] [Full Text]  
  • Vazquez-Torres, A., Fantuzzi, G., Edwards, C. K. III, Dinarello, C. A., Fang, F. C. (2001). Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages. Proc. Natl. Acad. Sci. USA 98: 2561-2565 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»