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Infect Immun, July 1998, p. 3355-3364, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Susceptibility to Salmonella typhimurium Infection and Effectiveness of Vaccination in Mice Deficient in the Tumor Necrosis Factor Alpha p55 Receptor

Paul Everest, Mark Roberts,dagger and Gordon Dougan*

Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AZ, United Kingdom

Received 10 September 1997/Returned for modification 17 November 1997/Accepted 22 April 1998

Mice defective in the ability to produce the tumor necrosis factor alpha p55 receptor (TNFalpha p55R) were orally challenged with a number of Salmonella typhimurium HWSH derivatives that differ in virulence. In comparison to TNFalpha p55R+/+ mice, TNFalpha p55R-/- mice succumbed earlier to challenge with wild-type S. typhimurium HWSH and S. typhimurium HWSH purE. In contrast, TNFalpha p55R-/- mice were able to control an S. typhimurium HWSH aroA challenge, although greater numbers of Salmonella organisms were present in the tissues for a longer time period than was observed with TNFalpha p55R+/+ mice. Vaccination of normal and TNFalpha p55R knockout animals with S. typhimurium HWSH aroA showed that TNFalpha p55R-/- mice, unlike TNFalpha p55R+/+ mice, were not protected against a virulent S. typhimurium HWSH challenge. Splenocytes from TNFalpha p55R-/- mice exhibited a reduced ability to proliferate in the presence of S. typhimurium antigen compared to TNFalpha p55R+/+ mice. Thus, TNFalpha p55R is essential for controlling Salmonella growth in tissues and for recall of immunity in murine salmonellosis.

* Corresponding author. Mailing address: Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AZ, United Kingdom. Phone: 44 171 594 5254. Fax: 44 171 594 5255. E-mail: g.dougan{at}ic.ac.uk.

dagger Present address: Department of Veterinary Pathology, Glasgow University Veterinary School, Glasgow G61 1QH, United Kingdom.

Infect Immun, July 1998, p. 3355-3364, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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