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Infect Immun, July 1998, p. 3403-3409, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Low Genetic Diversity of Haemophilus influenzae Type b Compared to Nonencapsulated H. influenzae in a Population in Which H. influenzae Is Highly Endemic

Heidi C. Smith-Vaughan,* Kadaba S. Sriprakash, Amanda J. Leach, John D. Mathews, and David J. Kemp

Menzies School of Health Research, Darwin, Northern Territory, Australia

Received 28 May 1997/Returned for modification 8 August 1997/Accepted 14 April 1998

Immunization with Haemophilus influenzae type b (Hib) conjugate polysaccharide vaccines has dramatically reduced Hib disease worldwide. As in other populations, nasopharyngeal carriage of Hib declined markedly in Aboriginal infants following vaccination, although carriage has not been entirely eliminated. In this study, we describe the genetic characteristics and the carriage dynamics of longitudinal isolates of Hib, characterized by using several typing methods. In addition, carriage rates of nonencapsulated H. influenzae (NCHi) are high, and concurrent colonization with Hib and NCHi is common; we also observed NCHi isolates which were genetically similar to Hib. There is a continuing need to promote Hib immunization and monitor H. influenzae carriage in populations in which the organism is highly endemic, not least because of the possibility of genetic exchange between Hib and NCHi strains in such populations.

* Corresponding author. Mailing address: Menzies School of Health Research, P.O. Box 41096, Casuarina NT 0811, Australia. Phone: 61 889 228 196. Fax: 61 889 275 187. E-mail: heidi{at}menzies.su.edu.au.

Infect Immun, July 1998, p. 3403-3409, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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J. Bacteriol. J. Virol. Eukaryot. Cell
Microbiol. Mol. Biol. Rev. Clin. Vaccine Immunol. All ASM Journals

Copyright © 1998 by the American Society for Microbiology. All rights reserved.