IAI FigSearch
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Giardina, P. C.
Right arrow Articles by Apicella, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Giardina, P. C.
Right arrow Articles by Apicella, M. A.

 Previous Article  |  Next Article 

Infect Immun, July 1998, p. 3416-3419, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Neisseria gonorrhoeae Induces Focal Polymerization of Actin in Primary Human Urethral Epithelium

Peter C. Giardina,1 Richard Williams,2 David Lubaroff,2 and Michael A. Apicella1,*

Department of Microbiology1 and Department of Urology,2 University of Iowa School of Medicine, Iowa City, Iowa 52242-1109

Received 5 March 1998/Accepted 2 April 1998

The pathogenic Neisseria species induce cytoskeletal reorganization in immortalized cell lines. In Chang conjunctival epithelium and T84 intestinal epithelium, focal cytoskeletal rearrangements in which bacteria contacted the epithelial surface were observed. We show that actin footprints are induced in gonococcus-challenged primary urethral epithelium. Moreover, the microbes induced microvillus extension from the epithelial cell surface. Our results indicate that formation of actin footprints is not an artifact of commonly used immortalized cell lines.

* Corresponding author. Mailing address: Department of Microbiology, University of Iowa School of Medicine, 51 Newton Rd., Iowa City, IA 52242-1109. Phone: (319) 335-7807. Fax: (319) 335-9006. E-mail: Michael-Apicella{at}uiowa.edu.

Infect Immun, July 1998, p. 3416-3419, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. J. Virol. Eukaryot. Cell
Microbiol. Mol. Biol. Rev. Clin. Vaccine Immunol. All ASM Journals

Copyright © 1998 by the American Society for Microbiology. All rights reserved.