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Infect Immun, July 1998, p. 3457-3461, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Protection of Mice against Plasmodium yoelii Sporozoite Challenge with P. yoelii Merozoite Surface Protein 1 DNA Vaccines

Sylvia I. Becker,1,dagger Ruobing Wang,1 Richard C. Hedstrom,1 Joao C. Aguiar,1,2 Trevor R. Jones,1 Stephen L. Hoffman,1,* and Malcolm J. Gardner1,3,Dagger

Malaria Program, Naval Medical Research Institute, Bethesda, Maryland 20889-56071; Pan American Health Organization, Washington, D.C. 200372; and Department of Microbiology and Immunology, University of Maryland at Baltimore, Baltimore, Maryland 21201-15593

Received 13 November 1997/Returned for modification 22 January 1998/Accepted 10 April 1998

Immunization of mice with DNA vaccines encoding the full-length form and C and N termini of Plasmodium yoelii merozoite surface protein 1 provided partial protection against sporozoite challenge and resulted in boosting of antibody titers after challenge. In C57BL/6 mice, two DNA vaccines provided protection comparable to that of recombinant protein consisting of the C terminus in Freund's adjuvant.

* Corresponding author. Mailing address: Malaria Program, Naval Medical Research Institute, 12300 Washington Ave., Rockville, MD 20852. Phone: (301) 295-0026. Fax: (301) 295-6171. E-mail: hoffmans{at}nmripo.nmri.nnmc.navy.mil.

dagger Present address: 2356 E. Seneca St., Tucson, AZ 85719.

Dagger Present address: The Institute for Genomic Research, Rockville, MD 20850.

Infect Immun, July 1998, p. 3457-3461, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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