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Infect Immun, July 1998, p. 3467-3469, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Nonspecific Early Protective Immunity in Francisella and Listeria Infections Can Be Dependent on Lymphocytes

Karen L. Elkins,* Ann T. MacIntyre, and Tonya R. Rhinehart-Jones

Laboratory of Mycobacteria, Division of Bacterial Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852

Received 23 September 1997/Returned for modification 20 February 1998/Accepted 24 April 1998

Normal mice, but not lymphocyte-deficient or B-cell-deficient mice, given a sublethal infection of Francisella tularensis LVS survive a secondary lethal challenge of more than 10,000 50% lethal doses given 3 days later. In this work, we show that similar early protection that is also strongly lymphocyte dependent operates in Listeria monocytogenes infection. Since sublethal infection with either LVS or L. monocytogenes protects against heterologous lethal challenge, this early protection is nonspecific.

* Corresponding author. Mailing address: Laboratory of Mycobacteria, Division of Bacterial Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM 431, Rockville, MD 20852. Phone: (301) 496-0544. Fax: (301) 402-2776. E-mail: elkins{at}cber.fda.gov.

Infect Immun, July 1998, p. 3467-3469, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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  • Dreisbach, V. C., Cowley, S., Elkins, K. L. (2000). Purified Lipopolysaccharide from Francisella tularensis Live Vaccine Strain (LVS) Induces Protective Immunity against LVS Infection That Requires B Cells and Gamma Interferon. Infect. Immun. 68: 1988-1996 [Abstract] [Full Text]  
  • Elkins, K. L., Bosio, C. M., Rhinehart-Jones, T. R. (1999). Importance of B cells, but Not Specific Antibodies, in Primary and Secondary Protective Immunity to the Intracellular Bacterium Francisella tularensis Live Vaccine Strain. Infect. Immun. 67: 6002-6007 [Abstract] [Full Text]  
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