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Infect Immun, July 1998, p. 3480-3484, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Inhibition of Class II Major Histocompatibility Complex Antigen Processing by Escherichia coli Heat-Labile Enterotoxin Requires an Enzymatically Active A Subunit

Milita P. Matousek,1 John G. Nedrud,1 Witold Cieplak Jr.,2,dagger and Clifford V. Harding1,*

Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106,1 and Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 598402

Received 7 November 1997/Returned for modification 23 December 1997/Accepted 24 March 1998

Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT) were found to inhibit intracellular antigen processing. Processing was not inhibited by mutant LT with attenuated ADP-ribosyltransferase activity, CT B or LT B subunit, which enhanced presentation of preexisting cell surface peptide-class II major histocompatibility complex complexes. Inhibition of antigen processing correlated with A subunit ADP-ribosyltransferase activity.

* Corresponding author. Mailing address: Institute of Pathology, Case Western Reserve University, 2085 Adelbert Rd., Cleveland, OH 44106. Phone: (216) 368-4711. Fax: (216) 368-0495. E-mail: cvh3{at}po.cwru.edu.

dagger Present address: Antigen Discovery and Evaluation, RIBI Immunochem Research, Hamilton, MT 59840.

Infect Immun, July 1998, p. 3480-3484, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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