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Infect Immun, August 1998, p. 3523-3526, Vol. 66, No. 8
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

CD1 Presents Antigens from a Gram-Negative Bacterium, Haemophilus influenzae Type b

Rick M. Fairhurst,1 2 Chun X. Wang,2 Pete A. Sieling,3 Robert L. Modlin,3 and Jonathan Braun1 2 *

Molecular Biology Institute,1 Department of Pathology and Laboratory Medicine,2 and Departments of Medicine and Microbiology and Immunology,3 UCLA School of Medicine, Los Angeles, California 90095

Received 10 October 1997/Returned for modification 16 January 1998/Accepted 7 May 1998

Human CD1 is a family of nonpolymorphic major histocompatibility complex class I-like molecules capable of presenting mycobacterial lipids, including lipoarabinomannan (LAM), to double-negative (DN; CD4- CD8-) as well as CD8+ T cells. Structural similarities between LAM and the capsular polysaccharides of gram-negative bacteria led us to consider the latter as candidate CD1 ligands. We derived two CD1-restricted DN T-cell populations which proliferated to Haemophilus influenzae type b (Hib) antigen. One T-cell population also proliferated to proteinase K-treated Hib antigen, suggesting that it recognized a nonpeptide. Our work thus expands the universe of T cell antigens to include nonpeptides distinct from mycobacterial lipids and suggests a potential role for CD1-restricted T cells in immunity to Hib.

* Corresponding author. Mailing address: Department of Pathology and Laboratory Medicine, UCLA School of Medicine, CHS 13-222, 10833 Le Conte Ave., Los Angeles, CA 90095-1732. Phone: (310) 825-0650. Fax: (310) 206-0657. E-mail: jbraun{at}pathology.medsch.ucla.edu.

Infect Immun, August 1998, p. 3523-3526, Vol. 66, No. 8
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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