IAI FigSearch
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Huber, M.
Right arrow Articles by Lohoff, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Huber, M.
Right arrow Articles by Lohoff, M.

 Previous Article  |  Next Article 

Infect Immun, August 1998, p. 3968-3970, Vol. 66, No. 8
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Effective and Long-Lasting Immunity against the Parasite Leishmania major in CD8-Deficient Mice

Magdalena Huber,1 Emma Timms,2 Tak W. Mak,2 Martin Röllinghoff,1 and Michael Lohoff1 *

Institut für Klinische Mikrobiologie und Immunologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany,1 and Ontario Cancer Institute, Amgen Research Institute, and the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada2

Received 21 January 1998/Returned for modification 2 March 1998/Accepted 6 May 1998

The results of earlier investigations that tested whether CD8+ T cells are required in the defense against Leishmania major have been inconsistent. We used CD8-deficient mice to directly address this issue. After primary infection with L. major, CD8-deficient mice controlled the infection for over 1 year and mounted strong T helper 1 cell responses. Thus, CD8+ T cells are not required for the long-term control of a primary infection with L. major.

* Corresponding author. Mailing address: Institut für Klinische Mikrobiologie und Immunologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Wasserturmstr. 3, 91054 Erlangen, Germany. Phone: 49/9131/85 2552. Fax: 49/9131/85 2573. E-mail: Michael.Lohoff{at}mikrobio.med.uni-erlangen.de.

Infect Immun, August 1998, p. 3968-3970, Vol. 66, No. 8
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. J. Virol. Eukaryot. Cell
Microbiol. Mol. Biol. Rev. Clin. Vaccine Immunol. All ASM Journals

Copyright © 1998 by the American Society for Microbiology. All rights reserved.