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Infect Immun, August 1998, p. 3968-3970, Vol. 66, No. 8
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Effective and Long-Lasting Immunity against the Parasite Leishmania major in CD8-Deficient Mice

Magdalena Huber,1 Emma Timms,2 Tak W. Mak,2 Martin Röllinghoff,1 and Michael Lohoff1 *

Institut für Klinische Mikrobiologie und Immunologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany,1 and Ontario Cancer Institute, Amgen Research Institute, and the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada2

Received 21 January 1998/Returned for modification 2 March 1998/Accepted 6 May 1998

The results of earlier investigations that tested whether CD8+ T cells are required in the defense against Leishmania major have been inconsistent. We used CD8-deficient mice to directly address this issue. After primary infection with L. major, CD8-deficient mice controlled the infection for over 1 year and mounted strong T helper 1 cell responses. Thus, CD8+ T cells are not required for the long-term control of a primary infection with L. major.

* Corresponding author. Mailing address: Institut für Klinische Mikrobiologie und Immunologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Wasserturmstr. 3, 91054 Erlangen, Germany. Phone: 49/9131/85 2552. Fax: 49/9131/85 2573. E-mail: Michael.Lohoff{at}mikrobio.med.uni-erlangen.de.

Infect Immun, August 1998, p. 3968-3970, Vol. 66, No. 8
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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