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Infect Immun, August 1998, p. 3981-3984, Vol. 66, No. 8
IRIS, Chiron Vaccines, 53100 Siena, Italy
Received 14 November 1997/Returned for modification 6 January
1998/Accepted 10 February 1998
The vacuolating cytotoxin of Helicobacter pylori, VacA,
enters the cytoplasm of target cells and causes vacuolar degeneration by interfering with late stages of endocytosis. By using indirect immunofluorescence and flow cytometry, we have demonstrated that VacA
binds to specific high-affinity cell surface receptors and that this
interaction is necessary for cell intoxication.
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Binding of the Helicobacter pylori
Vacuolating Cytotoxin to Target Cells
*
Corresponding author. Mailing address: IRIS, Chiron
Vaccines, Via Fiorentina 1, 53100 Siena, Italy. Phone: 39 577 243470. Fax: 39 577 243564. E-mail: Telford{at}iris02.biocine.it.
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