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Infect Immun, August 1998, p. 3995-3999, Vol. 66, No. 8
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Immune Responses in Ileostomy Fluid and Serum after Oral Cholera Vaccination of Patients Colectomized because of Ulcerative Colitis

Jan Kilhamn,1 2 Hans Brevinge,3 Ann-Mari Svennerholm,1 and Marianne Jertborn1 2 *

Departments of Medical Microbiology and Immunology,1 Infectious Diseases,2 and Surgery,3 Göteborg University, Göteborg, Sweden

Received 23 December 1997/Returned for modification 18 February 1998/Accepted 22 May 1998

The capacity of an oral inactivated B-subunit-whole-cell cholera vaccine to induce immune responses in patients colectomized due to ulcerative colitis was studied. Two doses of vaccine induced significant mucosal immunoglobulin A (IgA) antibody responses in ileostomy fluid against cholera toxin in 14 of 15 (93%) patients and against whole vibrios in 9 of 15 (60%) cases. The serological responses were lower (but not significantly) than those observed in healthy Swedish volunteers. Increased IgA antitoxin levels were found in ileostomy fluid as late as 2 years after vaccination.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, Göteborg University, Guldhedsgatan 10, S-413 46 Göteborg, Sweden. Phone: 46-31-60 46 81. Fax: 46-31-82 69 76. E-mail: marianne.jertborn{at}microbio.gu.se.

Infect Immun, August 1998, p. 3995-3999, Vol. 66, No. 8
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Wassen, L., Jertborn, M. (2005). Kinetics of Local and Systemic Immune Responses after Vaginal Immunization with Recombinant Cholera Toxin B Subunit in Humans. CVI 12: 447-452 [Abstract] [Full Text]  
  • Kilhamn, J., Lundin, S. B., Brevinge, H., Svennerholm, A.-M., Jertborn, M. (2003). T- and B-Cell Immune Responses of Patients Who Had Undergone Colectomies to Oral Administration of Salmonella enterica Serovar Typhi Ty21a Vaccine. CVI 10: 426-430 [Abstract] [Full Text]  
  • Kilhamn, J., Brevinge, H., Quiding-Jarbrink, M., Svennerholm, A.-M., Jertborn, M. (2001). Induction and Distribution of Intestinal Immune Responses after Administration of Recombinant Cholera Toxin B Subunit in the Ileal Pouches of Colectomized Patients. Infect. Immun. 69: 3466-3471 [Abstract] [Full Text]  


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