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Infection and Immunity, September 1998, p. 4093-4099, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Cloned Lines of Plasmodium berghei ANKA Differ in Their Abilities To Induce Experimental Cerebral Malaria

Véronique Amani,1 Mariama Idrissa Boubou,1 Sylviane Pied,1 Myriam Marussig,1 David Walliker,2 Dominique Mazier,1 and Laurent Rénia1,*

INSERM U313 and Department of Parasitology, Groupe Hospitalier Pitié-Salpêtrière, 75013 Paris, France,1 and Department of Genetics, Institute of Cell, Animal and Population, University of Edinburgh, Edinburgh EH9 3JN, United Kingdom2

Received 22 January 1998/Returned for modification 16 March 1998/Accepted 10 June 1998

Infection with Plasmodium berghei ANKA is usually lethal. The parasite causes in some mouse strains a neurovascular syndrome, experimental cerebral malaria (ECM), involving immunopathological reactions. The effects on the development of ECM of the mouse genetic background have been clearly demonstrated, but nothing is known about the effects of the clonal diversity of the parasite. We showed that various cloned lines derived from a polyclonal line of P. berghei ANKA caused ECM but that the extent of ECM induction was dependent on the amount of inoculum. Subtle differences in ECM characteristics (survival time and hypothermia) were also observed. We also confirmed, using the 1.49L cloned line, that the mouse genetic background strongly affects ECM.

* Corresponding author. Mailing address: INSERM U445, Institut Cochin de Génétique Moléculaire, Hôpital Cochin, Bâtiment Gustave Roussy, 27, rue du Fg Saint Jacques, 75014 Paris, France. Phone: 33 1 40 46 93 09. Fax: 33 1 44 07 14 25. E-mail: renia{at}icgm.cochin.inserm.fr.

Infection and Immunity, September 1998, p. 4093-4099, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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