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Infection and Immunity, September 1998, p. 4093-4099, Vol. 66, No. 9
INSERM U313 and Department of Parasitology,
Groupe Hospitalier Pitié-Salpêtrière, 75013 Paris, France,1 and
Department of
Genetics, Institute of Cell, Animal and Population, University of
Edinburgh, Edinburgh EH9 3JN, United
Kingdom2
Received 22 January 1998/Returned for modification 16 March
1998/Accepted 10 June 1998
Infection with Plasmodium berghei ANKA is usually
lethal. The parasite causes in some mouse strains a neurovascular
syndrome, experimental cerebral malaria (ECM), involving
immunopathological reactions. The effects on the development of ECM of
the mouse genetic background have been clearly demonstrated, but
nothing is known about the effects of the clonal diversity of the
parasite. We showed that various cloned lines derived from a polyclonal line of P. berghei ANKA caused ECM but that the extent of
ECM induction was dependent on the amount of inoculum. Subtle
differences in ECM characteristics (survival time and
hypothermia) were also observed. We also confirmed, using the 1.49L
cloned line, that the mouse genetic background strongly
affects ECM.
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Cloned Lines of Plasmodium berghei ANKA
Differ in Their Abilities To Induce Experimental Cerebral
Malaria
*
Corresponding author. Mailing address: INSERM U445,
Institut Cochin de Génétique Moléculaire,
Hôpital Cochin, Bâtiment Gustave Roussy, 27, rue du Fg
Saint Jacques, 75014 Paris, France. Phone: 33 1 40 46 93 09. Fax: 33 1 44 07 14 25. E-mail: renia{at}icgm.cochin.inserm.fr.
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