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Infection and Immunity, September 1998, p. 4499-4502, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Starvation Selection Restores Elastase and Rhamnolipid Production in a Pseudomonas aeruginosa Quorum-Sensing Mutant

Christian Van Delden, Everett C. Pesci, James P. Pearson, and Barbara H. Iglewski*

Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642

Received 6 May 1998/Returned for modification 5 June 1998/Accepted 15 June 1998

The las quorum-sensing system of Pseudomonas aeruginosa controls the expression of elastase and rhamnolipid. We report that starvation can select a mutant producing these virulence factors in spite of a lasR deletion. Expression of the autoinducer synthase gene rhlI was increased in this suppressor mutant, suggesting compensation by the rhl system. These data show that P. aeruginosa can restore elastase and rhamnolipid production in the absence of a functional las quorum-sensing system.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Rochester, 601 Elmwood Ave., Rochester, NY 14642. Phone: (716) 275-3402. Fax: (716) 473-9573. E-mail: BIGL{at}uhura.cc.rochester.edu.

Infection and Immunity, September 1998, p. 4499-4502, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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