This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Van Delden, C.
Right arrow Articles by Iglewski, B. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Van Delden, C.
Right arrow Articles by Iglewski, B. H.

 Previous Article  |  Next Article 

Infection and Immunity, September 1998, p. 4499-4502, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Starvation Selection Restores Elastase and Rhamnolipid Production in a Pseudomonas aeruginosa Quorum-Sensing Mutant

Christian Van Delden, Everett C. Pesci, James P. Pearson, and Barbara H. Iglewski*

Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642

Received 6 May 1998/Returned for modification 5 June 1998/Accepted 15 June 1998

The las quorum-sensing system of Pseudomonas aeruginosa controls the expression of elastase and rhamnolipid. We report that starvation can select a mutant producing these virulence factors in spite of a lasR deletion. Expression of the autoinducer synthase gene rhlI was increased in this suppressor mutant, suggesting compensation by the rhl system. These data show that P. aeruginosa can restore elastase and rhamnolipid production in the absence of a functional las quorum-sensing system.


* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Rochester, 601 Elmwood Ave., Rochester, NY 14642. Phone: (716) 275-3402. Fax: (716) 473-9573. E-mail: BIGL{at}uhura.cc.rochester.edu.


Infection and Immunity, September 1998, p. 4499-4502, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.



This article has been cited by other articles:

  • Dekimpe, V., Deziel, E. (2009). Revisiting the quorum-sensing hierarchy in Pseudomonas aeruginosa: the transcriptional regulator RhlR regulates LasR-specific factors. Microbiology 155: 712-723 [Abstract] [Full Text]  
  • Jeannot, K., Elsen, S., Kohler, T., Attree, I., van Delden, C., Plesiat, P. (2008). Resistance and Virulence of Pseudomonas aeruginosa Clinical Strains Overproducing the MexCD-OprJ Efflux Pump. Antimicrob. Agents Chemother. 52: 2455-2462 [Abstract] [Full Text]  
  • Kohler, T., Dumas, J.-L., Van Delden, C. (2007). Ribosome Protection Prevents Azithromycin-Mediated Quorum-Sensing Modulation and Stationary-Phase Killing of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 51: 4243-4248 [Abstract] [Full Text]  
  • Sandoz, K. M., Mitzimberg, S. M., Schuster, M. (2007). From the Cover: Social cheating in Pseudomonas aeruginosa quorum sensing. Proc. Natl. Acad. Sci. USA 104: 15876-15881 [Abstract] [Full Text]  
  • Bottomley, M. J., Muraglia, E., Bazzo, R., Carfi, A. (2007). Molecular Insights into Quorum Sensing in the Human Pathogen Pseudomonas aeruginosa from the Structure of the Virulence Regulator LasR Bound to Its Autoinducer. J. Biol. Chem. 282: 13592-13600 [Abstract] [Full Text]  
  • Lujan, A. M., Moyano, A. J., Segura, I., Argarana, C. E., Smania, A. M. (2007). Quorum-sensing-deficient (lasR) mutants emerge at high frequency from a Pseudomonas aeruginosa mutS strain. Microbiology 153: 225-237 [Abstract] [Full Text]  
  • Kong, K.-F., Jayawardena, S. R., Indulkar, S. D., del Puerto, A., Koh, C.-L., Hoiby, N., Mathee, K. (2005). Pseudomonas aeruginosa AmpR Is a Global Transcriptional Factor That Regulates Expression of AmpC and PoxB {beta}-Lactamases, Proteases, Quorum Sensing, and Other Virulence Factors. Antimicrob. Agents Chemother. 49: 4567-4575 [Abstract] [Full Text]  
  • Denervaud, V., TuQuoc, P., Blanc, D., Favre-Bonte, S., Krishnapillai, V., Reimmann, C., Haas, D., van Delden, C. (2004). Characterization of Cell-to-Cell Signaling-Deficient Pseudomonas aeruginosa Strains Colonizing Intubated Patients. J. Clin. Microbiol. 42: 554-562 [Abstract] [Full Text]  
  • Jude, F., Kohler, T., Branny, P., Perron, K., Mayer, M. P., Comte, R., van Delden, C. (2003). Posttranscriptional Control of Quorum-Sensing-Dependent Virulence Genes by DksA in Pseudomonas aeruginosa. J. Bacteriol. 185: 3558-3566 [Abstract] [Full Text]  
  • D'Argenio, D. A., Calfee, M. W., Rainey, P. B., Pesci, E. C. (2002). Autolysis and Autoaggregation in Pseudomonas aeruginosa Colony Morphology Mutants. J. Bacteriol. 184: 6481-6489 [Abstract] [Full Text]  
  • Beatson, S. A., Whitchurch, C. B., Semmler, A. B. T., Mattick, J. S. (2002). Quorum Sensing Is Not Required for Twitching Motility in Pseudomonas aeruginosa. J. Bacteriol. 184: 3598-3604 [Abstract] [Full Text]  
  • Cahan, R., Axelrad, I., Safrin, M., Ohman, D. E., Kessler, E. (2001). A Secreted Aminopeptidase of Pseudomonas aeruginosa. IDENTIFICATION, PRIMARY STRUCTURE, AND RELATIONSHIP TO OTHER AMINOPEPTIDASES. J. Biol. Chem. 276: 43645-43652 [Abstract] [Full Text]  
  • Kohler, T., van Delden, C., Curty, L. K., Hamzehpour, M. M., Pechere, J.-C. (2001). Overexpression of the MexEF-OprN Multidrug Efflux System Affects Cell-to-Cell Signaling in Pseudomonas aeruginosa. J. Bacteriol. 183: 5213-5222 [Abstract] [Full Text]  
  • Tateda, K., Comte, R., Pechere, J.-C., Köhler, T., Yamaguchi, K., Van Delden, C. (2001). Azithromycin Inhibits Quorum Sensing in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 45: 1930-1933 [Abstract] [Full Text]  
  • De Kievit, T. R., Gillis, R., Marx, S., Brown, C., Iglewski, B. H. (2001). Quorum-Sensing Genes in Pseudomonas aeruginosa Biofilms: Their Role and Expression Patterns. Appl. Environ. Microbiol. 67: 1865-1873 [Abstract] [Full Text]  
  • Bollinger, N., Hassett, D. J., Iglewski, B. H., Costerton, J. W., McDermott, T. R. (2001). Gene Expression in Pseudomonas aeruginosa: Evidence of Iron Override Effects on Quorum Sensing and Biofilm-Specific Gene Regulation. J. Bacteriol. 183: 1990-1996 [Abstract] [Full Text]  
  • Branny, P., Pearson, J. P., Pesci, E. C., Köhler, T., Iglewski, B. H., Van Delden, C. (2001). Inhibition of Quorum Sensing by a Pseudomonas aeruginosa dksA Homologue. J. Bacteriol. 183: 1531-1539 [Abstract] [Full Text]  
  • de Kievit, T. R., Iglewski, B. H. (2000). Bacterial Quorum Sensing in Pathogenic Relationships. Infect. Immun. 68: 4839-4849 [Full Text]  
  • McKnight, S. L., Iglewski, B. H., Pesci, E. C. (2000). The Pseudomonas Quinolone Signal Regulates rhl Quorum Sensing in Pseudomonas aeruginosa. J. Bacteriol. 182: 2702-2708 [Abstract] [Full Text]  
  • Rumbaugh, K. P., Griswold, J. A., Iglewski, B. H., Hamood, A. N. (1999). Contribution of Quorum Sensing to the Virulence of Pseudomonas aeruginosa in Burn Wound Infections. Infect. Immun. 67: 5854-5862 [Abstract] [Full Text]