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Infection and Immunity, September 1998, p. 4503-4506, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Protective Effect of Vaccination with a Combination of Recombinant Surface Antigen 1 and Interleukin-12 against Toxoplasmosis in Mice

Valerie Letscher-Bru,1 Odile Villard,1,* Bernhard Risse,2 Michael Zauke,2 Jean-Paul Klein,3 and Truong T. Kien1

Institut de Parasitologie et de Pathologie Tropicale, Inserm U392, Faculté de Médecine,1 and Faculté de Pharmacie,3 67000 Strasbourg, France, and Roche Diagnostics, Basel, Switzerland2

Received 17 February 1998/Returned for modification 27 March 1998/Accepted 5 June 1998

We studied the immune response induced in mice by recombinant Toxoplasma gondii surface antigen 1 (rSAG1) protein, alone or combined with interleukin-12 (IL-12) as an adjuvant, and the protective effect against toxoplasmosis. Immunization with rSAG1 alone induced a specific humoral type 2 immunity and did not protect the animals from infection. In contrast, immunization with rSAG1 plus IL-12 redirected humoral and cellular immunity toward a type 1 pattern and reduced the brain parasite load by 40%.

* Corresponding author. Mailing address: Institut de Parasitologie et de Pathologie Tropicale, Faculté de Médecine de Strasbourg, 3, rue Koeberlé, 67000 Strasbourg, France. Phone: 33-3-88-35-35-55. Fax: 33-3-88-36-42-02.

Infection and Immunity, September 1998, p. 4503-4506, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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