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Infection and Immunity, September 1998, p. 4507-4510, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Antibody Responses in Humans against Coli Surface Antigen 6 of Enterotoxigenic Escherichia coli

Anna Helander,1,* Christine Wennerås,1 Firdausi Qadri,2 and Ann-Mari Svennerholm1

Department of Medical Microbiology and Immunology, Göteborg University, Göteborg, Sweden,1 and the International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh2

Received 12 November 1997/Returned for modification 21 January 1998/Accepted 17 June 1998

Enterotoxigenic Escherichia coli (ETEC) strains expressing only coli surface antigen 6 (CS6) have previously been isolated from patients with diarrhea, but the immunogenicity of CS6 has not been established in humans. We have detected CS6-specific immunoglobulin A responses in the feces and blood of patients convalescing from natural ETEC disease and of volunteers given an oral ETEC vaccine.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, Göteborg University, Guldhedsgatan 10A, 413 46 Göteborg, Sweden. Phone: 46 31 60 47 19. Fax: 46 31 82 69 76. E-mail: anna.helander{at}microbio.gu.se.

Infection and Immunity, September 1998, p. 4507-4510, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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