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Infection and Immunity, September 1998, p. 4522-4525, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Elevated Concentrations of Eotaxin and Interleukin-5 in Human Neurocysticercosis

Carlton A. W. Evans,1,dagger Hector H. Garcia,2,3 Adele Hartnell,4 Robert H. Gilman,2,5,6 Peter J. Jose,4 Manuel Martinez,3 Daniel G. Remick,7 Timothy J. Williams,4 and Jon S. Friedland1,*

Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital,1 and Department of Applied Pharmacology, Imperial College School of Medicine, National Heart and Lung Institute,4 London, United Kingdom; Department of Microbiology and Pathology, Universidad Cayetano Heredia,2 Instituto National de Ciencias Neurologicas,3 and AB Prisma,6 Lima, Peru; Department of International Health, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland5; and Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan7

Received 23 March 1998/Returned for modification 22 April 1998/Accepted 19 June 1998

Symptomatic neurocysticercosis, a major cause of epilepsy worldwide, results from inflammation around Taenia solium larvae, but the mechanisms are unknown. Eotaxin, not previously reported in cases of human infection, and interleukin-5 (IL-5) but not IL-8 concentrations were elevated in patient serum, and IL-5 levels were also elevated in cerebrospinal fluid (CSF). Eosinophil-selective mediators may be involved in the pathogenesis of cysticercosis. IL-6 concentrations were also elevated in patient CSF, possibly indicative of an acute-phase response.

* Corresponding author. Mailing address: Department of Infectious Diseases, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom. Phone: 44 181 383 8521. Fax: 44 181 383 3394. E-mail: j.friedland{at}rpms.ac.uk.

dagger Present address: University of Cambridge Clinical School, Department of Medicine, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom.

Infection and Immunity, September 1998, p. 4522-4525, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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