IAI FigSearch
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tarrab-Hazdai, R.
Right arrow Articles by Arnon, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tarrab-Hazdai, R.
Right arrow Articles by Arnon, R.

 Previous Article  |  Next Article 

Infection and Immunity, September 1998, p. 4526-4530, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Synthesis and Characterization of a Protective Peptide-Based Vaccine against Schistosoma mansoni

Rebeca Tarrab-Hazdai, Deborah Schechtman, and Ruth Arnon*

Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel

Received 13 April 1998/Returned for modification 13 May 1998/Accepted 30 June 1998

Two synthetic peptides, corresponding to the N-terminal sequence of the 45-kDa subunit of the protective 9B antigen of Schistosoma mansoni and differing in only one amino acid residue, were synthesized. These peptides were recognized by the protective monoclonal antibody 152-66-9B, as well as by sera of mice and humans infected with schistosomiasis. The peptides were coupled to a protein carrier and used for immunization. One of the peptides, 9B-peptide1, induced in mice significant protection against challenge infection, manifested in a 40 to 50% reduction in worm burden.

* Corresponding author. Mailing address: Immunology Department, The Weizmann Institute of Science, P.O.B. 26, Rehovot 76100, Israel. Phone: 972-8-934 4017. Fax: 972-8-934 4141. E-mail: liarnon{at}weizmann.weizman.ac.il.

Infection and Immunity, September 1998, p. 4526-4530, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. J. Virol. Eukaryot. Cell
Microbiol. Mol. Biol. Rev. Clin. Vaccine Immunol. All ASM Journals

Copyright © 1998 by the American Society for Microbiology. All rights reserved.