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Infection and Immunity, September 1998, p. 4526-4530, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Synthesis and Characterization of a Protective Peptide-Based Vaccine against Schistosoma mansoni

Rebeca Tarrab-Hazdai, Deborah Schechtman, and Ruth Arnon*

Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel

Received 13 April 1998/Returned for modification 13 May 1998/Accepted 30 June 1998

Two synthetic peptides, corresponding to the N-terminal sequence of the 45-kDa subunit of the protective 9B antigen of Schistosoma mansoni and differing in only one amino acid residue, were synthesized. These peptides were recognized by the protective monoclonal antibody 152-66-9B, as well as by sera of mice and humans infected with schistosomiasis. The peptides were coupled to a protein carrier and used for immunization. One of the peptides, 9B-peptide1, induced in mice significant protection against challenge infection, manifested in a 40 to 50% reduction in worm burden.

* Corresponding author. Mailing address: Immunology Department, The Weizmann Institute of Science, P.O.B. 26, Rehovot 76100, Israel. Phone: 972-8-934 4017. Fax: 972-8-934 4141. E-mail: liarnon{at}weizmann.weizman.ac.il.

Infection and Immunity, September 1998, p. 4526-4530, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Ben-Yedidia, T., Tarrab-Hazdai, R., Schechtman, D., Arnon, R. (1999). Intranasal Administration of Synthetic Recombinant Peptide-Based Vaccine Protects Mice from Infection by Schistosoma mansoni. Infect. Immun. 67: 4360-4366 [Abstract] [Full Text]  


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