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Infection and Immunity, September 1998, p. 4537-4540, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Increased Capacity for Interleukin-2 Synthesis Parallels Disease Progression in Mice Infected with Leishmania major

Frederick P. Heinzel,* Ronald M. Rerko, Andrea M. Hujer, and Richard A. Maier Jr.

Division of Geographic Medicine, Case Western Reserve University School of Medicine, and the VA Medical Center, Cleveland, Ohio 44106

Received 1 April 1998/Returned for modification 5 May 1998/Accepted 8 June 1998

Lymph node cells of BALB/c mice with progressive leishmaniasis produced sixfold more interleukin-2 (IL-2) in culture than those of healing C57BL/6 mice. IL-2 synthesis also increased in C57BL/6 mice made susceptible by IL-12 or gamma interferon deficiency. However, IL-2 mRNA levels in vivo did not reflect IL-2 production in vitro. Because IL-2 contributes to the pathogenesis of progressive leishmaniasis, the functional significance of these findings should be further explored.

* Corresponding author. Mailing address: Division of Geographic Medicine W-137, Case Western Reserve University School of Medicine, Cleveland, OH 44106-4983. Phone: (216) 368-1859. Fax: (216) 368-4825. E-mail: fxh10{at}po.cwru.edu.

Infection and Immunity, September 1998, p. 4537-4540, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.




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