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Infection and Immunity, September 1998, p. 4541-4544, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Role of CR4 in Mycobacterium tuberculosis-Human Macrophages Binding and Signal Transduction in the Absence of Serum

Yona Zaffran,1,* Li Zhang,2 and Jerrold J. Ellner1

Department of Medicine, Case Western Reserve University, and University Hospitals, Cleveland, Ohio 44106-4984,1 and Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, The Cleveland Clinic Foundation, Cleveland, Ohio 441952

Received 25 March 1998/Returned for modification 14 April 1998/Accepted 18 June 1998

The beta 2 integrin CR4 is involved in Mycobacterium tuberculosis phagocytosis by human mononuclear phagocytes through the opsonin C3bi. In this study, we demonstrate that M. tuberculosis can bind directly to monocyte-derived macrophages via CR4 in the absence of any opsonins. CR4-transfected CHO cells gave similar results, suggesting recognition by CR4 of bacterial structure. Furthermore, binding of M. tuberculosis transduced a potent signal, resulting in tyrosine phosphorylation of macrophage proteins, which was in part mediated by CR4.

* Corresponding author. Present address: Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, The Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195. Phone: (216) 445-5139. Fax: (216) 445-2051. E-mail: zaffray{at}cesmtp.ccf.org.

Infection and Immunity, September 1998, p. 4541-4544, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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