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Infection and Immunity, September 1998, p. 4549-4552, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

The Macrophage-Induced Gene mig as a Marker for Clinical Pathogenicity and In Vitro Virulence of Mycobacterium avium Complex Strains

Martin Meyer,1 Philipp W. R. von Grünberg,1 Tim Knoop,1 Pia Hartmann,2 and Georg Plum1,*

Institut für Medizinische Mikrobiologie und Hygiene1 and Medizinische Klinik I,2 Universität zu Köln, D-50935 Cologne, Germany

Received 26 January 1998/Returned for modification 19 March 1998/Accepted 26 June 1998

The capacity of 20 Mycobacterium avium complex isolates to multiply intracellularly in human monocyte-derived macrophages was assessed and correlated to the clinical relevance of each isolate and its reactivity with several candidate genetic virulence markers. The strongest correlation with a virulence phenotype was found for a conserved coding sequence of the macrophage-induced gene mig identified by a specific mig restriction fragment length polymorphism type.

* Corresponding author. Mailing address: Institut für Medizinische Mikrobiologie und Hygiene der Universität zu Köln, Goldenfelsstrasse 21, D-50935 Cologne, Germany. Phone: 49-221-478-3009. Fax: 49-221-438156. E-mail: gplum{at}uni-koeln.de.

Infection and Immunity, September 1998, p. 4549-4552, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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