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Infection and Immunity, September 1998, p. 4553-4556, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Paclitaxel (Taxol)-Induced Killing of Leishmania major in Murine Macrophages

T. Mark Doherty,1 Alan Sher,1 and Stefanie N. Vogel2,*

Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892,1 and Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 208142

Received 23 March 1998/Returned for modification 5 May 1998/Accepted 16 June 1998

The antitumor drug paclitaxel (Taxol) has been demonstrated to be a lipopolysaccharide mimetic in murine macrophages. In this study, the capacity of paclitaxel to activate macrophages to become microbicidal for Leishmania major was examined. Paclitaxel and gamma interferon synergized to kill intracellular L. major in Lpsn, but not Lpsd, macrophages by a nitric oxide (NO·)-dependent mechanism.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814. Phone: (301) 295-3446. Fax: (301) 295-1545. E-mail: vogel{at}usuhsb.usuhs.mil.

Infection and Immunity, September 1998, p. 4553-4556, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

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  • Bhat, N., Perera, P.-Y., Carboni, J. M., Blanco, J., Golenbock, D. T., Mayadas, T. N., Vogel, S. N. (1999). Use of a Photoactivatable Taxol Analogue to Identify Unique Cellular Targets in Murine Macrophages: Identification of Murine CD18 as a Major Taxol-Binding Protein and a Role for Mac-1 in Taxol-Induced Gene Expression. J. Immunol. 162: 7335-7342 [Abstract] [Full Text]  
  • Kantakamalakul, W., Politis, A. D., Marecki, S., Sullivan, T., Ozato, K., Fenton, M. J., Vogel, S. N. (1999). Regulation of IFN Consensus Sequence Binding Protein Expression in Murine Macrophages. J. Immunol. 162: 7417-7425 [Abstract] [Full Text]  
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