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Infection and Immunity, September 1998, p. 4557-4559, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

E and P Selectins Are Not Required for Resistance to Severe Murine Lyme Arthritis

Kathleen Petri Seiler,1,dagger Ying Ma,1 John H. Weis,1 Paul S. Frenette,2 Richard O. Hynes,3 Denisa D. Wagner,2 and Janis J. Weis1,*

Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah,1 and Center for Blood Research, Department of Pathology, Harvard Medical School, Boston,2 and Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge,3 Massachusetts

Received 8 May 1998/Returned for modification 8 June 1998/Accepted 18 June 1998

Borrelia burgdorferi-induced arthritis in mice is characterized by tendonitis, synovitis, and inflammatory-cell infiltrate, predominantly of neutrophils. Because genetic deficiency in E and P selectins results in delayed recruitment of neutrophils to sites of inflammation, mice with this deficiency were tested for their response to infection with B. burgdorferi. E and P selectins were not required for the control of B. burgdorferi numbers, nor did deficiency in E and P selectins result in alteration of arthritis severity.

* Corresponding author. Mailing address: Department of Pathology, University of Utah School of Medicine, 50 N. Medical Dr., Salt Lake City, UT 84132. Phone: (801) 581-8386. Fax: (801) 581-4517. E-mail: janis.weis{at}path.med.utah.edu.

dagger Present address: Pikeville College School of Osteopathic Medicine, Pikeville, Ky.

Infection and Immunity, September 1998, p. 4557-4559, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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