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Infection and Immunity, September 1998, p. 4564-4567, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

A Role for Interleukin-6 in Host Defense against Murine Chlamydia trachomatis Infection

Dwight M. Williams,1,2,* Barry G. Grubbs,1,2 Toni Darville,3 Kathleen Kelly,3 and Roger G. Rank3

Division of Infectious Diseases, Audie L. Murphy Memorial Veterans Hospital,1 and Department of Medicine, University of Texas Health Sciences Center at San Antonio,2 San Antonio, Texas 78284, and Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 722053

Received 12 January 1998/Returned for modification 13 March 1998/Accepted 8 June 1998

Interleukin-6-deficient (IL-6-/-) knockout mice had significantly increased Chlamydia trachomatis levels in lung tissue and increased mortality compared to B6129F2/J controls early after intranasal infection. Gamma interferon production and chlamydia-specific antibody levels were consistent with a decreased but reversible Th1-like response in IL-6-/- mice. IL-6 is needed for an optimal early host response to this infection.

* Corresponding author. Mailing address: Division of Infectious Diseases, Audie L. Murphy Memorial Veterans Hospital, 7400 Merton Minter Blvd., San Antonio, TX 78284. Phone: (210) 617-5109. Fax: (210) 949-3303. E-mail: dwight.williams{at}med.

Infection and Immunity, September 1998, p. 4564-4567, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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