This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Akin, E.
Right arrow Articles by Steere, A. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Akin, E.
Right arrow Articles by Steere, A. C.

 Previous Article  |  Next Article 

Infection and Immunity, January 1999, p. 173-181, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

The Immunoglobulin (IgG) Antibody Response to OspA and OspB Correlates with Severe and Prolonged Lyme Arthritis and the IgG Response to P35 Correlates with Mild and Brief Arthritis

Evren Akin,1,* Gail L. McHugh,2 Richard A. Flavell,3 Erol Fikrig,4 and Allen C. Steere2

Divisions of Rheumatology/Immunology and Pediatric Rheumatology1 and Division of Rheumatology/Immunology,2 Tufts University School of Medicine, New England Medical Center, Tupper Research Institute, Boston, Massachusetts, and Howard Hughes Medical Institute3 and Division of Rheumatology,4 Yale University School of Medicine, New Haven, Connecticut

Received 17 July 1998/Accepted 23 September 1998

In an effort to implicate immune responses to specific Borrelia burgdorferi proteins that may have a role in chronic Lyme arthritis, we studied the natural history of the antibody response to B. burgdorferi in serial serum samples from 25 patients monitored throughout the course of Lyme disease. In these patients, the immunoglobulin G (IgM) and IgG antibody responses to 10 recombinant B. burgdorferi proteins, determined during early infection, early arthritis, and maximal arthritis, were correlated with the severity and duration of maximal arthritis. The earliest responses were usually to outer surface protein C (OspC), P35, P37, and P41; reactivity with OspE, OspF, P39, and P93 often developed weeks later; and months to years later, 64% of patients had responses to OspA and OspB. During early infection and early arthritis, the levels of IgG antibody to P35 correlated inversely with the subsequent severity or duration of maximal arthritis. In contrast, during periods of maximal arthritis, the levels of IgG antibody to OspA and OspB, especially to a C-terminal epitope of OspA, correlated directly with the severity and duration of arthritis. Thus, the higher the IgG antibody response to P35 earlier in the infection, the milder and briefer the subsequent arthritis, whereas during maximal arthritis, the higher the IgG response to OspA and OspB, the more severe and prolonged the arthritis.

* Corresponding author. Mailing address: Division of Rheumatology/Immunology, New England Medical Center, NEMC 406, 750 Washington St., Boston, MA 02111. Phone: (617) 636-5789. Fax: (617) 636-4252.

Infection and Immunity, January 1999, p. 173-181, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Ledue, T. B., Collins, M. F., Young, J., Schriefer, M. E. (2008). Evaluation of the Recombinant VlsE-Based Liaison Chemiluminescence Immunoassay for Detection of Borrelia burgdorferi and Diagnosis of Lyme Disease. CVI 15: 1796-1804 [Abstract] [Full Text]  
  • Kotloski, N. J., Nardelli, D. T., Peterson, S. H., Torrealba, J. R., Warner, T. F., Callister, S. M., Schell, R. F. (2008). Interleukin-23 Is Required for Development of Arthritis in Mice Vaccinated and Challenged with Borrelia Species. CVI 15: 1199-1207 [Abstract] [Full Text]  
  • Sterba, J., Vancova, M., Rudenko, N., Golovchenko, M., Tremblay, T.-L., Kelly, J. F., MacKenzie, C. R., Logan, S. M., Grubhoffer, L. (2008). Flagellin and Outer Surface Proteins from Borrelia burgdorferi Are Not Glycosylated. J. Bacteriol. 190: 2619-2623 [Abstract] [Full Text]  
  • Nardelli, D. T., Callister, S. M., Schell, R. F. (2008). Lyme Arthritis: Current Concepts and a Change in Paradigm. CVI 15: 21-34 [Full Text]  
  • Iliopoulou, B. P., Alroy, J., Huber, B. T. (2007). CD28 Deficiency Exacerbates Joint Inflammation upon Borrelia burgdorferi Infection, Resulting in the Development of Chronic Lyme Arthritis. J. Immunol. 179: 8076-8082 [Abstract] [Full Text]  
  • Hsieh, Y.-F., Liu, H.-W., Hsu, T.-C., Wei, J. C.-C., Shih, C.-M., Krause, P. J., Tsay, G. J. (2007). Serum Reactivity against Borrelia burgdorferi OspA in Patients with Rheumatoid Arthritis. CVI 14: 1437-1441 [Abstract] [Full Text]  
  • Feder, H. M. Jr., Johnson, B. J.B., O'Connell, S., Shapiro, E. D., Steere, A. C., Wormser, G. P., the Ad Hoc International Lyme Disease Group, (2007). A Critical Appraisal of "Chronic Lyme Disease". NEJM 357: 1422-1430 [Full Text]  
  • Strother, K. O., Hodzic, E., Barthold, S. W., de Silva, A. M. (2007). Infection of Mice with Lyme Disease Spirochetes Constitutively Producing Outer Surface Proteins A and B. Infect. Immun. 75: 2786-2794 [Abstract] [Full Text]  
  • Peterson, S. H., Nardelli, D. T., Warner, T. F., Callister, S. M., Torrealba, J. R., Schell, R. F. (2007). Anti-p19 Antibody Treatment Exacerbates Lyme Arthritis and Enhances Borreliacidal Activity. CVI 14: 510-517 [Abstract] [Full Text]  
  • Hashimoto, M., Furuyashiki, M., Kaseya, R., Fukada, Y., Akimaru, M., Aoyama, K., Okuno, T., Tamura, T., Kirikae, T., Kirikae, F., Eiraku, N., Morioka, H., Fujimoto, Y., Fukase, K., Takashige, K., Moriya, Y., Kusumoto, S., Suda, Y. (2007). Evidence of Immunostimulating Lipoprotein Existing in the Natural Lipoteichoic Acid Fraction. Infect. Immun. 75: 1926-1932 [Abstract] [Full Text]  
  • Ghosh, S., Seward, R., Costello, C. E., Stollar, B. D., Huber, B. T. (2006). Autoantibodies from Synovial Lesions in Chronic, Antibiotic Treatment-Resistant Lyme Arthritis Bind Cytokeratin-10. J. Immunol. 177: 2486-2494 [Abstract] [Full Text]  
  • Li, X., Liu, X., Beck, D. S., Kantor, F. S., Fikrig, E. (2006). Borrelia burgdorferi Lacking BBK32, a Fibronectin-Binding Protein, Retains Full Pathogenicity.. Infect. Immun. 74: 3305-3313 [Abstract] [Full Text]  
  • Steere, A. C., Klitz, W., Drouin, E. E., Falk, B. A., Kwok, W. W., Nepom, G. T., Baxter-Lowe, L. A. (2006). Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide. JEM 203: 961-971 [Abstract] [Full Text]  
  • Aguero-Rosenfeld, M. E., Wang, G., Schwartz, I., Wormser, G. P. (2005). Diagnosis of Lyme Borreliosis. Clin. Microbiol. Rev. 18: 484-509 [Abstract] [Full Text]  
  • Salazar, C. A., Rothemich, M., Drouin, E. E., Glickstein, L., Steere, A. C. (2005). Human Lyme Arthritis and the Immunoglobulin G Antibody Response to the 37-Kilodalton Arthritis-Related Protein of Borrelia burgdorferi. Infect. Immun. 73: 2951-2957 [Abstract] [Full Text]  
  • Becker, M., Bunikis, J., Lade, B. D., Dunn, J. J., Barbour, A. G., Lawson, C. L. (2005). Structural Investigation of Borrelia burgdorferi OspB, a BactericidalFab Target. J. Biol. Chem. 280: 17363-17370 [Abstract] [Full Text]  
  • Ramamoorthy, R., McClain, N. A., Gautam, A., Scholl-Meeker, D. (2005). Expression of the bmpB Gene of Borrelia burgdorferi Is Modulated by Two Distinct Transcription Termination Events. J. Bacteriol. 187: 2592-2600 [Abstract] [Full Text]  
  • MAGNARELLI, L. A., LAWRENZ, M., NORRIS, S. J., FIKRIG, E. (2002). Comparative reactivity of human sera to recombinant VlsE and other Borrelia burgdorferi antigens in class-specific enzyme-linked immunosorbent assays for Lyme borreliosis. J Med Microbiol 51: 649-655 [Abstract] [Full Text]  
  • Liang, F. T., Nelson, F. K., Fikrig, E. (2002). Molecular Adaptation of Borrelia burgdorferi in the Murine Host. JEM 196: 275-280 [Abstract] [Full Text]  
  • Heikkila, T., Seppala, I., Saxen, H., Panelius, J., Peltomaa, M., Julin, T., Carlsson, S.-A., Lahdenne, P. (2002). Recombinant BBK32 Protein in Serodiagnosis of Early and Late Lyme Borreliosis. J. Clin. Microbiol. 40: 1174-1180 [Abstract] [Full Text]  
  • Vaz, A., Glickstein, L., Field, J. A., McHugh, G., Sikand, V. K., Damle, N., Steere, A. C. (2001). Cellular and Humoral Immune Responses to Borrelia burgdorferi Antigens in Patients with Culture-Positive Early Lyme Disease. Infect. Immun. 69: 7437-7444 [Abstract] [Full Text]  
  • MAGNARELLI, L. A., LEVY, S. A., IJDO, J. W., WU, C., PADULA, S. J., FIKRIG, E. (2001). Reactivity of dog sera to whole-cell or recombinant antigens of Borrelia burgdorferi by ELISA and immunoblot analysis. J Med Microbiol 50: 889-895 [Abstract] [Full Text]  
  • Steere, A. C. (2001). Lyme Disease. NEJM 345: 115-125 [Full Text]  
  • Mbow, M. L., Zeidner, N., Gilmore, R. D. Jr., Dolan, M., Piesman, J., Titus, R. G. (2001). Major Histocompatibility Complex Class II-Independent Generation of Neutralizing Antibodies against T-Cell-Dependent Borrelia burgdorferi Antigens Presented by Dendritic Cells: Regulation by NK and {gamma}{delta} T Cells. Infect. Immun. 69: 2407-2415 [Abstract] [Full Text]  
  • Liang, F. T., Jacobs, M. B., Philipp, M. T. (2001). C-Terminal Invariable Domain of VlsE May Not Serve as Target for Protective Immune Response against Borrelia burgdorferi. Infect. Immun. 69: 1337-1343 [Abstract] [Full Text]  
  • Parenti, D. L., Schell, R. F., Callister, S. M., Lovrich, S. D. (2000). Outer Surface Protein A and Arthritis in Hamsters. Infect. Immun. 68: 7212-7213 [Full Text]  
  • Damman, C. J., Eggers, C. H., Samuels, D. S., Oliver, D. B. (2000). Characterization of Borrelia burgdorferi BlyA and BlyB Proteins: a Prophage-Encoded Holin-Like System. J. Bacteriol. 182: 6791-6797 [Abstract] [Full Text]  
  • Hovius, J. W. R., Hovius, K. E., Oei, A., Houwers, D. J., van Dam, A. P. (2000). Antibodies against Specific Proteins of and Immobilizing Activity against Three Strains of Borrelia burgdorferi Sensu Lato Can Be Found in Symptomatic but Not in Infected Asymptomatic Dogs. J. Clin. Microbiol. 38: 2611-2621 [Abstract] [Full Text]  
  • Fikrig, E., Feng, W., Barthold, S. W., Telford, S. R. III, Flavell, R. A. (2000). Arthropod- and Host-Specific Borrelia burgdorferi bbk32 Expression and the Inhibition of Spirochete Transmission. J. Immunol. 164: 5344-5351 [Abstract] [Full Text]  
  • Magnarelli, L. A., Ijdo, J. W., Padula, S. J., Flavell, R. A., Fikrig, E. (2000). Serologic Diagnosis of Lyme Borreliosis by Using Enzyme-Linked Immunosorbent Assays with Recombinant Antigens. J. Clin. Microbiol. 38: 1735-1739 [Abstract] [Full Text]  
  • Croke, C. L., Munson, E. L., Lovrich, S. D., Christopherson, J. A., Remington, M. C., England, D. M., Callister, S. M., Schell, R. F. (2000). Occurrence of Severe Destructive Lyme Arthritis in Hamsters Vaccinated with Outer Surface Protein A and Challenged with Borrelia burgdorferi. Infect. Immun. 68: 658-663 [Abstract] [Full Text]  
  • Hellwage, J., Meri, T., Heikkila, T., Alitalo, A., Panelius, J., Lahdenne, P., Seppala, I. J. T., Meri, S. (2001). The Complement Regulator Factor H Binds to the Surface Protein OspE of Borrelia burgdorferi. J. Biol. Chem. 276: 8427-8435 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»