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Infection and Immunity, January 1999, p. 266-270, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Polarized Helper-T-Cell Responses against Leishmania major in the Absence of B Cells

Daniel R. Brown,1 and Steven L. Reiner1,2,3,*

Department of Medicine,2 Committee on Developmental Biology,3 and Committee on Immunology,1 The University of Chicago, Chicago, Illinois 60637

Received 13 August 1998/Returned for modification 1 October 1998/Accepted 30 October 1998

B-cell-to-T-cell signaling can shape helper T (Th) cell responses. During infection with Leishmania major, Th response is critical in determining the outcome of disease. Resistance depends on the generation of a protective Th1 response, while susceptibility is mediated by the generation of a Th2 response. In this study, we determined whether B cells are required for the development of polarized Th1 and Th2 responses during infection with L. major. Mice lacking B cells due to disruption of the immunoglobulin M locus (µMT) were infected with L. major, and disease progression and Th cell development were assessed. On the genetically resistant C57BL background, both wild-type and µMT mice controlled the infection and mounted a Th1 response. On the genetically susceptible BALB/c background, both wild-type and µMT mice were susceptible to infection and generated Th2 responses. Thus, during L. major infection, neither direct antigen presentation or costimulation by B cells nor antibody-mediated effector functions are essential for the development of polarized Th responses.

* Corresponding author. Mailing address: Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637-5420. Phone: (773) 702-4728. Fax: (773) 702-1576. E-mail: sreiner{at}midway.uchicago.edu.

Infection and Immunity, January 1999, p. 266-270, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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