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Infection and Immunity, January 1999, p. 337-341, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Helicobacter pylori Infection in Immunized Mice Lacking Major Histocompatibility Complex Class I and Class II Functions

Jacques Pappo,* Deirdre Torrey, Lillian Castriotta, Anneli Savinainen, Zita Kabok, and Alexander Ibraghimov

Mucosal Immunology, Astra Research Center Boston, Inc., Cambridge, Massachusetts 02139

Received 13 August 1998/Accepted 14 October 1998

The role of major histocompatibility complex (MHC) class I- and class II-restricted functions in Helicobacter pylori infection and immunity upon oral immunization was examined in vivo. Experimental challenge with H. pylori SS1 resulted in significantly greater (P <=  0.025) colonization of MHC class I and class II mutant mice than C57BL/6 wild-type mice. Oral immunization with H. pylori whole-cell lysates and cholera toxin adjuvant significantly reduced the magnitude of H. pylori infection in C57BL/6 wild-type (P = 0.0083) and MHC class I knockout mice (P = 0.0048), but it had no effect on the H. pylori infection level in MHC class II-deficient mice. Analysis of the anti-H. pylori antibody levels in serum showed a dominant serum immunoglobulin G1 (IgG1) response in immunized C57BL/6 wild-type and MHC class I mutant mice but no detectable serum IgG response in MHC class II knockout mice. Populations of T-cell-receptor (TCR) alpha beta + CD4+ CD54+ cells localized to gastric tissue of immunized C57BL/6 wild-type and MHC class I knockout mice, but TCRalpha beta + CD8+ cells predominated in the gastric tissue of immunized MHC class II-deficient mice. These observations show that CD4+ T cells engaged after mucosal immunization may be important for the generation of a protective anti-H. pylori immune response and that CD4+ CD8- and CD4- CD8+ T cells regulate the extent of H. pylori infection in vivo.

* Corresponding author. Mailing address: Mucosal Immunology, Astra Research Center Boston, Inc., 128 Sidney St., Cambridge, MA 02139. Phone: (617) 234-2533. Fax: (617) 576-3030. E-mail: jack.pappo{at}arcb.us.astra.com.

Infection and Immunity, January 1999, p. 337-341, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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