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Infection and Immunity, January 1999, p. 426-428, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Tonsillar Application of Formalin-Killed Cells of Streptococcus sobrinus Reduces Experimental Dental Caries in Rabbits

Takaki Fukuizumi,* Hiromasa Inoue, Toshiyuki Tsujisawa, and Choji Uchiyama

Department of Oral Bacteriology, Kyushu Dental College, Kitakyushu, Japan

Received 4 June 1998/Returned for modification 31 July 1998/Accepted 5 October 1998

Living Streptococcus sobrinus cells were orally inoculated into nonimmune rabbits and rabbits immunized with formalin-killed cells of S. sobrinus through tonsillar application to examine the anticaries potential of this method of immunization. The living S. sobrinus cell numbers and the caries areas in the rabbits immunized by tonsillar application decreased to a level one-fifth of that in nonimmune rabbits.

* Corresponding author. Mailing address: Department of Oral Bacteriology, Kyushu Dental College, 2-6-1 Manazuru, Kokura-kita, Kitakyushu, Fukuoka 803-8580, Japan. Phone: 81-93-582-1131. Fax: 81-93-581-4984. E-mail: izumi{at}kyu-dent.ac.jp.

Infection and Immunity, January 1999, p. 426-428, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Smith, D.J. (2002). DENTAL CARIES VACCINES: PROSPECTS AND CONCERNS. CROBM 13: 335-349 [Abstract] [Full Text]  
  • Mettens, P., Monteyne, P. (2002). Life-style vaccines. Br Med Bull 62: 175-186 [Abstract] [Full Text]  
  • Childers, N.K., Tong, G., Li, F., Dasanayake, A.P., Kirk, K., Michalek, S.M. (2002). Humans Immunized with Streptococcus mutans Antigens by Mucosal Routes. JDR 81: 48-52 [Abstract] [Full Text]  
  • Fukuizumi, T., Inoue, H., Tsujisawa, T., Uchiyama, C. (2000). Streptococcus sobrinus Antigens That React to Salivary Antibodies Induced by Tonsillar Application of Formalin-Killed S. sobrinus in Rabbits. Infect. Immun. 68: 725-731 [Abstract] [Full Text]  


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