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Infection and Immunity, January 1999, p. 433-435, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Nonrestricted Differential Intoxication of Cells by Pertussis Toxin

Ali el Bayâ, Kerstin Brückener, and M. Alexander Schmidt*

Institut für Infektiologie - Zentrum für Molekularbiologie der Entzündung, Westfälische Wilhelms-Universität Münster, D-48149 Münster, Germany

Received 2 September 1998/Returned for modification 24 September 1998/Accepted 5 October 1998

After uptake and retrograde transport pertussis toxin acts by ADP-ribosylating alpha -Gi proteins. We show that uptake via many different receptor proteins followed by retrograde transport and intoxication is not restricted to a particular cell type. The efficiency of cellular intoxication, however, was found to be cell type dependent.

* Corresponding author. Mailing address: M. Alexander Schmidt, Institut für Infektiologie - ZMBE, Von-Esmarch-Str. 56, D-48149 Münster, Germany. Phone: 49-251-835 6466. Fax: 49-251 835 6467. E-mail: infekt{at}uni-muenster.de.

Infection and Immunity, January 1999, p. 433-435, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Bruckener, K. E., el Baya, A., Galla, H.-J., Schmidt, M. A. (2003). Permeabilization in a cerebral endothelial barrier model by pertussis toxin involves the PKC effector pathway and is abolished by elevated levels of cAMP. J. Cell Sci. 116: 1837-1846 [Abstract] [Full Text]  
  • Gao, J. F., Call, S. B., Fillmore, P. D., Watanabe, T., Meeker, N. D., Teuscher, C. (2003). Analysis of the Role of Bphs/Hrh1 in the Genetic Control of Responsiveness to Pertussis Toxin. Infect. Immun. 71: 1281-1287 [Abstract] [Full Text]  


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