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Infection and Immunity, January 1999, p. 446-448, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

gamma delta T-Cell Function in Pathogenesis of Cerebral Malaria in Mice Infected with Plasmodium berghei ANKA

D. M. Yañez, J. Batchelder, H. C. van der Heyde,dagger D. D. Manning, and W. P. Weidanz*

Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin

Received 15 June 1998/Returned for modification 23 July 1998/Accepted 28 September 1998

Mice depleted of gamma delta T cells by monoclonal antibody treatment and infected with Plasmodium berghei ANKA did not develop cerebral malaria (CM). In striking contrast, delta 0/0 mice infected with P. berghei developed CM despite their gamma delta T-cell deficiency. gamma delta T cells appear to be essential for the pathogenesis of CM in mice having experienced normal ontogeny but not in mice genetically deprived of gamma delta T cells from the beginning of life.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, University of Wisconsin---Madison, 436 Service Memorial Institutes, 1300 University Ave., Madison, WI 53706. Phone: (608) 262-9027. Fax: (608) 262-8418. E-mail: wweidanz{at}macc.wisc.edu.

dagger Present address: Department of Microbiology and Immunology, Louisiana State University Medical Center, Shreveport, LA 71103.

Infection and Immunity, January 1999, p. 446-448, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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