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Infection and Immunity, January 1999, p. 446-448, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

T-Cell Function in Pathogenesis of Cerebral
Malaria in Mice Infected with Plasmodium berghei
ANKA
D. M.
Yañez,
J.
Batchelder,
H. C.
van
der Heyde,
D. D.
Manning, and
W. P.
Weidanz*
Department of Medical Microbiology and
Immunology, University of Wisconsin Medical School, Madison, Wisconsin
Received 15 June 1998/Returned for modification 23 July
1998/Accepted 28 September 1998
Mice depleted of 
T cells by monoclonal antibody treatment
and infected with Plasmodium berghei ANKA did not develop
cerebral malaria (CM). In striking contrast,
0/0 mice
infected with P. berghei developed CM despite their 
T-cell deficiency. 
T cells appear to be essential for the
pathogenesis of CM in mice having experienced normal ontogeny but not
in mice genetically deprived of 
T cells from the beginning of life.
*
Corresponding author. Mailing address: Department of
Medical Microbiology and Immunology, University of Wisconsin
Madison, 436 Service Memorial Institutes, 1300 University Ave., Madison, WI
53706. Phone: (608) 262-9027. Fax: (608) 262-8418. E-mail: wweidanz{at}macc.wisc.edu.

Present address: Department of Microbiology and Immunology,
Louisiana State University Medical Center, Shreveport, LA
71103.
Infection and Immunity, January 1999, p. 446-448, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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