This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brady, M. T.
Right arrow Articles by Mills, K. H. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brady, M. T.
Right arrow Articles by Mills, K. H. G.

 Previous Article  |  Next Article 

Infection and Immunity, October 1999, p. 5372-5378, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Fasciola hepatica Suppresses a Protective Th1 Response against Bordetella pertussis

Miriam T. Brady,1 Sandra M. O'Neill,2 John P. Dalton,2 and Kingston H. G. Mills1,*

Infection and Immunity Group, Department of Biology, National University of Ireland, Maynooth, County Kildare,1 and School of Biotechnology, Dublin City University, Glasnevin, Dublin 9,2 Ireland

Received 18 May 1999/Returned for modification 16 June 1999/Accepted 23 July 1999

Fasciolosis, like other helminth infections, is associated with the induction of T-cell responses polarized to the Th2 subtype. Respiratory infection with Bordetella pertussis or immunization with a pertussis whole-cell vaccine (Pw) induces a potent Th1 response, which confers a high level of protection against bacterial challenge. We have used these two pathogens to examine bystander cross-regulation of Th1 and Th2 cells in vivo and provide evidence of immunomodulation of host T-cell responses to B. pertussis by a concomitant infection with Fasciola hepatica. Mice with a coinfection of F. hepatica and B. pertussis exhibited a Th2 cytokine profile in response to F. hepatica antigens, similar to those infected with F. hepatica alone. By contrast, the Th1 response to B. pertussis antigens was markedly suppressed and the bacterial infection was exacerbated following infection with F. hepatica. Furthermore, an established Th1 response induced in mice by infection with B. pertussis or by parenteral immunization with Pw was also suppressed following infection with F. hepatica. This immunomodulatory effect of B. pertussis-induced responses by F. hepatica infection is significantly reduced, but not completely abrogated, in IL-4 knockout mice. Our findings demonstrate that Th2-inducing parasites can exert bystander suppression of protective Th1 responses to infection or vaccination with a bacterial pathogen and that the modulation is mediated in part by IL-4 and, significantly, is effective at both the induction and effector stages of the Th1 response.

* Corresponding author. Mailing address: Infection and Immunity Group, Department of Biology, National University of Ireland, Maynooth, Co. Kildare, Ireland. Phone: 353-1-7083838. Fax: 353-1-7083845. E-mail: kingston.mills{at}may.ie.

Infection and Immunity, October 1999, p. 5372-5378, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Walsh, K. P., Brady, M. T., Finlay, C. M., Boon, L., Mills, K. H. G. (2009). Infection with a Helminth Parasite Attenuates Autoimmunity through TGF-{beta}-Mediated Suppression of Th17 and Th1 Responses. J. Immunol. 183: 1577-1586 [Abstract] [Full Text]  
  • Hamilton, C. M., Dowling, D. J., Loscher, C. E., Morphew, R. M., Brophy, P. M., O'Neill, S. M. (2009). The Fasciola hepatica Tegumental Antigen Suppresses Dendritic Cell Maturation and Function. Infect. Immun. 77: 2488-2498 [Abstract] [Full Text]  
  • Robinson, M. W., Tort, J. F., Lowther, J., Donnelly, S. M., Wong, E., Xu, W., Stack, C. M., Padula, M., Herbert, B., Dalton, J. P. (2008). Proteomics and Phylogenetic Analysis of the Cathepsin L Protease Family of the Helminth Pathogen Fasciola hepatica: Expansion of a Repertoire of Virulence-associated Factors. Mol. Cell. Proteomics 7: 1111-1123 [Abstract] [Full Text]  
  • Flynn, R. J., Mulcahy, G. (2008). Possible Role for Toll-Like Receptors in Interaction of Fasciola hepatica Excretory/Secretory Products with Bovine Macrophages. Infect. Immun. 76: 678-684 [Abstract] [Full Text]  
  • Weng, M., Huntley, D., Huang, I-F., Foye-Jackson, O., Wang, L., Sarkissian, A., Zhou, Q., Walker, W. A., Cherayil, B. J., Shi, H. N. (2007). Alternatively Activated Macrophages in Intestinal Helminth Infection: Effects on Concurrent Bacterial Colitis. J. Immunol. 179: 4721-4731 [Abstract] [Full Text]  
  • Stack, C. M., Donnelly, S., Lowther, J., Xu, W., Collins, P. R., Brinen, L. S., Dalton, J. P. (2007). The Major Secreted Cathepsin L1 Protease of the Liver Fluke, Fasciola hepatica: A LEU-12 TO PRO-12 REPLACEMENT IN THE NONCONSERVED C-TERMINAL REGION OF THE PROSEGMENT PREVENTS COMPLETE ENZYME AUTOACTIVATION AND ALLOWS DEFINITION OF THE MOLECULAR EVENTS IN PROSEGMENT REMOVAL. J. Biol. Chem. 282: 16532-16543 [Abstract] [Full Text]  
  • Flynn, R. J., Mannion, C., Golden, O., Hacariz, O., Mulcahy, G. (2007). Experimental Fasciola hepatica Infection Alters Responses to Tests Used for Diagnosis of Bovine Tuberculosis. Infect. Immun. 75: 1373-1381 [Abstract] [Full Text]  
  • Elliott, A. M, Kizza, M., Quigley, M. A, Ndibazza, J., Nampijja, M., Muhangi, L., Morison, L., Namujju, P. B, Muwanga, M., Kabatereine, N., Whitwortha, J. A. (2007). The impact of helminths on the response to immunization and on the incidence of infection and disease in childhood in Uganda: design of a randomized, double-blind, placebo-controlled, factorial trial of deworming interventions delivered in pregnancy and early childhood [ISRCTN32849447]. Clin Trials 4: 42-57 [Abstract]  
  • Chen, C.-C., Louie, S., McCormick, B., Walker, W. A., Shi, H. N. (2005). Concurrent Infection with an Intestinal Helminth Parasite Impairs Host Resistance to Enteric Citrobacter rodentium and Enhances Citrobacter-Induced Colitis in Mice. Infect. Immun. 73: 5468-5481 [Abstract] [Full Text]  
  • Donnelly, S., O'Neill, S. M., Sekiya, M., Mulcahy, G., Dalton, J. P. (2005). Thioredoxin Peroxidase Secreted by Fasciola hepatica Induces the Alternative Activation of Macrophages. Infect. Immun. 73: 166-173 [Abstract] [Full Text]  
  • Collins, P. R., Stack, C. M., O'Neill, S. M., Doyle, S., Ryan, T., Brennan, G. P., Mousley, A., Stewart, M., Maule, A. G., Dalton, J. P., Donnelly, S. (2004). Cathepsin L1, the Major Protease Involved in Liver Fluke (Fasciola hepatica) Virulence: PROPEPTIDE CLEAVAGE SITES AND AUTOACTIVATION OF THE ZYMOGEN SECRETED FROM GASTRODERMAL CELLS. J. Biol. Chem. 279: 17038-17046 [Abstract] [Full Text]  
  • Walzl, G., Tafuro, S., Moss, P., Openshaw, P. J.M., Hussell, T. (2000). Influenza Virus Lung Infection Protects from Respiratory Syncytial Virus-Induced Immunopathology. JEM 192: 1317-1326 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»